Source localization of auditory steady state response

听觉稳态响应的源定位

• 批准号: 6323078
• 负责人: SAMUEL D REYES
• 金额: $ 2万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-26 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6323078
• 关键词: auditory threshold; bioimaging /biomedical imaging; brain mapping; clinical research; electroencephalography; human subject; magnetic resonance imaging; positron emission tomography; psychoacoustics; sound perception

DESCRIPTION (from applicant's abstract): The auditory steady state response (aSSR) is an electrophysiologic measure of hearing that is gaining increased clinical use as an objective measure of audiologic threshold. Recent reports also suggest dysrythmias in synchronizing activity related to aSSRs may be a common mechanism in chronic pain, Parkinson's disease, and tinnitus. However, the generators of this potential are not fully understood. A more thorough understanding of the neuroanatomy and dynamics of the SSRs will improve their diagnostic value and may lead to new treatment methods for these conditions. The goal of this study is to map the areas and sequence of activation in the brain generating aSSR. Specifically, we will: 1. Use positron emission tomography (PET) to determine the location and distribution of neural structures involved in generating the aSSR. 2. Construct dynamic maps of the location and temporal sequence of activation in the neural network generating the aSSR by combining PET and EEG source localization methods. The electrical activity of the brain during the aSSR will be recorded from the scalp in eight subjects using a 64 channel computerized EEG system. MRI from each subject will provide a detailed anatomic image, clearly segmenting skin, skull, CSF, white matter, and gray matter. The MRI image will be used to construct realistic head models for performing EEG source localization and will serve as a common anatomical space in which to compare PET and EEG data. PET data will be collected using the same stimulus used to elicit the aSSR in the EEG recordings. PET data will also be collected for a quiet resting condition. Comparing the PET data for the aSSR and baseline conditions for significant activations will allow the determination of the neural structures involved in generating the aSSR. EEG source localization constrained by the PET data will then be used to create dynamic maps of the aSSR. These dynamic maps will show the contribution of each structure and the sequence of activation involved in generating the aSSR.

描述（来自申请人的摘要）：听觉稳态响应 (aSSR) 是一种听力电生理测量方法，其测量值正在增加 临床用作听力阈值的客观测量。最近的报告 还表明与 aSSR 相关的同步活动节律障碍可能是 慢性疼痛、帕金森病和耳鸣的常见机制。然而， 这种潜力的产生者尚未完全了解。更彻底的 对 SSR 的神经解剖学和动力学的理解将提高他们的能力 诊断价值，并可能为这些疾病带来新的治疗方法。这 这项研究的目标是绘制大脑激活区域和序列 生成aSSR。具体来说，我们将： 1. 使用正电子发射断层扫描 (PET) 确定所涉及神经结构的位置和分布 在生成 aSSR 时。 2. 构建位置和时间的动态地图 神经网络中的激活序列通过组合生成 aSSR PET 和 EEG 源定位方法。 aSSR 期间大脑的电活动将从 使用 64 通道计算机脑电图系统对 8 名受试者进行头皮分析。核磁共振成像来自 每个受试者将提供详细的解剖图像，清晰地分割皮肤， 头骨、脑脊液、白质和灰质。 MRI 图像将用于 构建用于执行脑电图源定位的真实头部模型，并将 作为比较 PET 和 EEG 数据的通用解剖空间。宠物 将使用与引发 aSSR 相同的刺激来收集数据 脑电图记录。还将在安静的休息条件下收集 PET 数据。 比较 aSSR 的 PET 数据和基线条件的显着性 激活将允许确定涉及的神经结构 生成 aSSR。受 PET 数据限制的 EEG 源定位将 然后用于创建 aSSR 的动态映射。这些动态地图将显示 每个结构的贡献和参与的激活顺序 生成 aSSR。