Semantic Memory and MRI Volumetrics in Epilepsy

癫痫的语义记忆和 MRI 体积测量

• 批准号: 6364603
• 负责人: BRIAN D BELL
• 金额: $ 8.26万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-06 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6364603
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; cognition; hippocampus; human subject; magnetic resonance imaging; memory; memory disorders; morphometry; neocortex; neuroanatomy; neuropsychology; partial seizure; patient oriented research; semantics; temporal lobe /cortex disorder

DESCRIPTION (provided by applicant): Early onset temporal lobe epilepsy (TLE) typically is associated with cognitive deficits and quantitative volumetric magnetic resonance imaging (MRI) abnormalities. Impairment of episodic memory, or new learning, and hippocampal atrophy are the best characterized of these cognitive and structural deficits. In contrast, abnormalities of semantic memory, or factual knowledge, have been studied much less systematically, and the neuroanatomic correlates of impaired semantic memory in TLE have yet to be reported. In this application for a Mentored PatientOriented Research Career Development Award, the candidate proposes an organized program of training and supervised research focusing on semantic memory and its neural substrate in TLE. While the applicant has experience in clinical neuropsychology, the proposal provides for additional training in research ethics, experimental cognitive neuropsychology, quantitative volumetric MRI processing, MRI diagnostics, clinical epilepsy, language development, and advanced statistical analysis. This training will be integrated with a research project that will: 1) Compare TLE patients and healthy controls on a comprehensive battery of semantic memory measures, 2) quantify MRI volumetric abnormalities in sub-regions of the temporal lobe, and 3) determine the relationship between the cognitive measures and lateral versus mesial (i.e., hippocampal) temporal lobe volumetrics. These findings will lead to improved detection of semantic knowledge deficits in clinical neuropsychological assessment and an advance understanding of the neural substrate of semantic memory. Finally, this award would provide the applicant with the background and training for an independent research career dedicated to elucidating the relationships in TLE patients among semantic memory, other cognitive abilities, and brain structure, and characterizing the implications of these relationships for social, educational, and occupational functioning.

描述（由申请人提供）：早发性颞叶癫痫 (TLE) 通常与认知缺陷和定量体积磁共振成像 (MRI) 异常有关。情景记忆受损， 或新的学习，而海马萎缩是其中最好的特征 认知和结构缺陷。相反，语义异常 记忆或事实知识的系统研究要少得多，并且 TLE 中语义记忆受损的神经解剖学相关性尚未确定 报道称。在这份以患者为导向的研究职业指导申请中 发展奖，候选人提出有组织的培训计划和 专注于语义记忆及其神经基础的监督研究 TLE。虽然申请人有临床神经心理学经验， 提案提供了研究伦理、实验等方面的额外培训 认知神经心理学、定量体积 MRI 处理、MRI 诊断、临床癫痫、语言发展和高级统计 分析。该培训将与一个研究项目相结合，该项目将： 1) 对 TLE 患者和健康对照进行全面的比较 语义记忆测量，2) 量化 MRI 体积异常 颞叶的子区域，3）确定之间的关系 认知测量以及外侧颞叶与内侧（即海马）颞叶 体积测量。这些发现将导致语义检测的改进 临床神经心理学评估的知识缺陷和进展 了解语义记忆的神经基础。最后，这个奖项 将为申请人提供独立的背景和培训 致力于阐明 TLE 患者之间关系的研究生涯 语义记忆、其他认知能力和大脑结构之间，以及 描述这些关系对社会、教育、 和职业功能。