Semantic Memory and MRI Volumetrics in Epilepsy

描述(申请人提供)：早发性颞叶癫痫(TLE) 通常与认知缺陷和定量容量磁共振成像(MRI)异常有关。情节记忆受损， 或新的学习，和海马体萎缩是这些最好的特征 认知和结构性缺陷。相比之下，语义的异常 记忆或事实知识的系统研究要少得多，而且 TLE患者语义记忆受损的神经解剖学相关性尚未得到证实 据报道。在本申请表中，我申请了一份面向临床的研究指导职业 发展奖，候选人提出了一个有组织的培训和 以语义记忆及其神经基础为中心的监督研究 TLE。虽然申请人在临床神经心理学方面有经验，但 提案规定了额外的研究伦理培训，试验性的 认知神经心理学，定量体积磁共振成像处理 诊断学、临床癫痫、语言发展和高级统计学 分析。该培训将与一个研究项目相结合，该项目将： 1)对TLE患者和健康对照组进行全面的 语义记忆测量，2)量化MRI体积异常 颞叶的子区域，以及3)决定了 认知测量和外侧与内侧(即海马区)颞叶 体积测量学。这些发现将有助于改进语义检测 临床神经心理学评估中的知识缺陷及其研究进展 理解语义记忆的神经基础。最后，这个奖项 会为申请者提供独立的背景和培训 致力于阐明TLE患者的关系的研究生涯 语义记忆、其他认知能力和大脑结构，以及 描述这些关系对社会、教育、 和职业功能。

DESCRIPTION (provided by applicant): Early onset temporal lobe epilepsy (TLE) typically is associated with cognitive deficits and quantitative volumetric magnetic resonance imaging (MRI) abnormalities. Impairment of episodic memory, or new learning, and hippocampal atrophy are the best characterized of these cognitive and structural deficits. In contrast, abnormalities of semantic memory, or factual knowledge, have been studied much less systematically, and the neuroanatomic correlates of impaired semantic memory in TLE have yet to be reported. In this application for a Mentored PatientOriented Research Career Development Award, the candidate proposes an organized program of training and supervised research focusing on semantic memory and its neural substrate in TLE. While the applicant has experience in clinical neuropsychology, the proposal provides for additional training in research ethics, experimental cognitive neuropsychology, quantitative volumetric MRI processing, MRI diagnostics, clinical epilepsy, language development, and advanced statistical analysis. This training will be integrated with a research project that will: 1) Compare TLE patients and healthy controls on a comprehensive battery of semantic memory measures, 2) quantify MRI volumetric abnormalities in sub-regions of the temporal lobe, and 3) determine the relationship between the cognitive measures and lateral versus mesial (i.e., hippocampal) temporal lobe volumetrics. These findings will lead to improved detection of semantic knowledge deficits in clinical neuropsychological assessment and an advance understanding of the neural substrate of semantic memory. Finally, this award would provide the applicant with the background and training for an independent research career dedicated to elucidating the relationships in TLE patients among semantic memory, other cognitive abilities, and brain structure, and characterizing the implications of these relationships for social, educational, and occupational functioning.