Cognitive and Pharmacotherapy for Suicidal Adolescents

自杀青少年的认知和药物治疗

• 批准号: 6326374
• 负责人: STEPHANIE S DANIEL
• 金额: $ 13.87万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6326374
• 关键词: adolescence (12-20); behavioral /social science research tag; clinical depression; clinical research; clinical trials; cognitive behavior therapy; combination therapy; data collection methodology /evaluation; education; human subject; human therapy evaluation; interview; mental disorder chemotherapy; mental disorder diagnosis; outcomes research; social support network; statistics /biometry; suicide

DESCRIPTION (provided by applicant): This application for a career development award describes a plan for training and research in the area of clinical trials among children and adolescents, and will allow the candidate to pursue a program of research examining the efficacy of two different combinations of treatments for depressed, suicidal adolescents. The primary objective of this development award is for the candidate to gain expertise as an independent investigator in psychiatric clinical trials, particularly with children and adolescents. On-site mentoring for this development award will be provided by Dr. David Goldston (primary mentor) and by Dr. Curt Furberg (mentor in clinical trials methodology). External mentors for this development award include Drs. John March and John Curry (Duke University Medical Center). External consultants for this development award include Drs. David Brent, Maria Kovacs, Graham Emslie and Thomas Ellis. The research study described in this application is designed to examine the feasibility and efficacy of two different combinations of treatment (combined cognitive-behavioral therapy and pharmacotherapy vs. combined supportive therapy and education and pharmacotherapy) for depressed, suicidal adolescents. A small randomized contolled trial will be used to test the hypothesis that combined cognitive-behavioral therapy and pharmacotherapy will be more efficacious than combined supportive therapy education and pharmacotherapy in decreasing adolescents' depressive symptoms and suicidal behaviors (including suicidal ideation).

描述（由申请人提供）：此职业发展申请 奖项描述了临床试验领域的培训和研究计划 在儿童和青少年中，并将允许候选人追求 研究计划检查两种不同组合的功效 对抑郁、自杀青少年的治疗。此举的首要目标 发展奖旨在让候选人获得作为独立人士的专业知识 精神病学临床试验的研究者，特别是针对儿童和 青少年。该发展奖的现场指导将由 David Goldston 博士（主要导师）和 Curt Furberg 博士（临床导师） 试验方法）。该发展奖的外部导师包括博士。 约翰·马奇和约翰·库里（杜克大学医学中心）。外部的 该发展奖的顾问包括博士。大卫·布伦特、玛丽亚·科瓦奇、 格雷厄姆·埃姆斯利和托马斯·埃利斯。本研究中描述的研究 该应用程序旨在检查两种方法的可行性和有效性 不同的治疗组合（结合认知行为疗法和 药物治疗与联合支持治疗和教育以及 药物疗法）针对抑郁、有自杀倾向的青少年。小型随机 对照试验将用于检验结合了以下假设的假设： 认知行为疗法和药物疗法比药物疗法更有效 联合支持治疗教育和药物治疗可减少 青少年的抑郁症状和自杀行为（包括自杀倾向） 构思）。