Genetic linkage of schizophrenia and related studies

这是对职业生涯中期研究者奖竞争性续展申请的修订，该奖项于 1995 年作为独立科学家奖 (K02) 提供资助，此次续展是根据患者相关研究的 K24 机制提出的。研究主题是精神分裂症和（最近）主要情绪障碍的遗传学合作研究。申请人是一名精神病学家，从事这些研究的家庭招募和临床评估、将统计遗传学的进步应用于临床研究的设计、以及组织和协调大型合作以收集新样本并对现有样本进行多中心连锁研究等方面的研究职业。申请人已转到具有出色研究和研究培训环境的机构。需要职业奖励支持，以提供足够的受保护时间，以专注于拟议的以患者为导向的研究计划，并积极参与指导刚开始的研究实习生。当前的奖励期包括完成精神分裂症的基因组扫描；在非常大的多中心样本中组织一系列精神分裂症候选区域的连锁研究；创建并初步测试精神障碍的新维度评级量表；近交群体情绪障碍的试点数据收集；从事计算机模拟研究；启动两个大型谱系收集，一个是重度抑郁症（作为六个站点合作的协调员），一个是精神分裂症（作为九个站点之一的 PI）；和辅导活动。拟议奖项提供的受保护时间将允许开发新的研究重点，重点是测量精神障碍中的精神病理学的维度方法，根据该领域的进展组织新的大型合作，开展职业发展活动以增强分子和统计遗传学知识，以及作为教师和导师参与资助的精神病学住院医师临床学者研究计划，为期四年的研究培训。其他活动将包括资助的多中心谱系收集和重度抑郁症和精神分裂症的基因组扫描；完成之前的精神分裂症基因组扫描项目；共同努力确定特定的易感基因；协调一个受资助的项目，以继续进行精神分裂症的多中心联系和关联研究；完成隔离人群情绪障碍数据采集并开发相关人群模拟软件和遗传分析策略。

This is a revision of a competing renewal application for a Midcareer Investigator Award which was funded as an Independent Scientist Award (K02) in 1995, with this renewal requested under the K24 mechanism for patient related research. The research theme has been collaborative studies in the genetics of schizophrenia and (more recently) major mood disorders. The applicant is a psychiatrist who has pursued a career of research in the recruitment and clinical assessment of families for these studies, the application of advances in statistical genetics to the design of clinical studies, and the organization and coordination of large collaborations to collect new samples and to carry out multicenter linkage studies of existing samples. The applicant has moved to an institution with an outstanding research and research training environment. Career award support is needed to provide sufficient protected time to focus on the proposed program of patient- oriented research and active involvement in mentoring of beginning research trainees. The current award period has included completion of a genome scan of schizophrenia; organization of a series of linkage studies of schizophrenia candidate regions in very large multicenter samples; creation and initial testing of a new dimensional rating scale for psychotic disorders; pilot data collection of mood disorders in an inbred population; work on computer simulation studies; initiation of two large pedigree collections, one of major depression (as coordinator of a six-site collaboration) and one of schizophrenia (as PI of one of nine sites); and mentoring activities. The protected time made possible by the proposed award will permit development of a new research focus on dimensional approaches to measuring psychopathology in psychotic disorders, organization of new large collaborations based on advances in the field, career development activities to enhance knowledge of molecular and statistical genetics, and participation as a teacher and mentor in a funded Clinical Scholars Research Program for psychiatry residents in a four-year research training track. Other activities will include the funded multicenter pedigree collections and genome scans of major depression and schizophrenia; completing a previous schizophrenia genome scan project; collaborative efforts to identify specific susceptibility genes; coordinating a funded project to continue multicenter linkage and association studies of schizophrenia; and completion of the isolated population mood disorders data collection and development of related population simulation software and genetic analysis strategies.