Genetic linkage of schizophrenia and related studies

精神分裂症的遗传连锁及相关研究

• 批准号: 6908263
• 负责人: DOUGLAS Frederick LEVINSON
• 金额: $ 4.49万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-30 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6908263
• 关键词: biotechnology; computer program /software; computer simulation; data collection; disease /disorder onset; family genetics; gene expression; genetic screening; genetic susceptibility; genotype; human genetic material tag; human population study; human subject; interview; linkage mapping; major depression; meta analysis; molecular genetics; patient oriented research; schizophrenia

This is a revision of a competing renewal application for a Midcareer Investigator Award which was funded as an Independent Scientist Award (K02) in 1995, with this renewal requested under the K24 mechanism for patient related research. The research theme has been collaborative studies in the genetics of schizophrenia and (more recently) major mood disorders. The applicant is a psychiatrist who has pursued a career of research in the recruitment and clinical assessment of families for these studies, the application of advances in statistical genetics to the design of clinical studies, and the organization and coordination of large collaborations to collect new samples and to carry out multicenter linkage studies of existing samples. The applicant has moved to an institution with an outstanding research and research training environment. Career award support is needed to provide sufficient protected time to focus on the proposed program of patient- oriented research and active involvement in mentoring of beginning research trainees. The current award period has included completion of a genome scan of schizophrenia; organization of a series of linkage studies of schizophrenia candidate regions in very large multicenter samples; creation and initial testing of a new dimensional rating scale for psychotic disorders; pilot data collection of mood disorders in an inbred population; work on computer simulation studies; initiation of two large pedigree collections, one of major depression (as coordinator of a six-site collaboration) and one of schizophrenia (as PI of one of nine sites); and mentoring activities. The protected time made possible by the proposed award will permit development of a new research focus on dimensional approaches to measuring psychopathology in psychotic disorders, organization of new large collaborations based on advances in the field, career development activities to enhance knowledge of molecular and statistical genetics, and participation as a teacher and mentor in a funded Clinical Scholars Research Program for psychiatry residents in a four-year research training track. Other activities will include the funded multicenter pedigree collections and genome scans of major depression and schizophrenia; completing a previous schizophrenia genome scan project; collaborative efforts to identify specific susceptibility genes; coordinating a funded project to continue multicenter linkage and association studies of schizophrenia; and completion of the isolated population mood disorders data collection and development of related population simulation software and genetic analysis strategies.

这是对1995年作为独立科学家奖（K 02）资助的职业中期研究者奖的竞争性续期申请的修订，该续期申请是根据K24机制为患者相关研究提出的。研究主题是精神分裂症和（最近）主要情绪障碍遗传学的合作研究。申请人是一名精神科医生，他从事研究工作，包括为这些研究招募和临床评估家庭，将统计遗传学的进步应用于临床研究的设计，以及组织和协调大型合作以收集新样本并对现有样本进行多中心连锁研究。申请人已经搬到一个具有出色的研究和研究培训环境的机构。职业奖励支持是必要的，以提供足够的保护时间，专注于拟议的计划，以病人为导向的研究和积极参与指导开始研究学员。目前的奖励期包括完成精神分裂症的基因组扫描;在非常大的多中心样本中组织一系列精神分裂症候选区域的连锁研究;创建和初步测试精神病的新维度评定量表;在近亲繁殖人口中收集情绪障碍的试点数据;计算机模拟研究工作;启动两个大型谱系收集，一个是重性抑郁症（作为六个地点协作的协调员），一个是精神分裂症（作为九个地点之一的PI）;以及指导活动。拟议的奖项所提供的受保护的时间将允许开发一个新的研究重点，即测量精神障碍中精神病理学的维度方法，根据该领域的进展组织新的大型合作，职业发展活动，以提高分子和统计遗传学的知识，并作为一名教师和导师参与了一个资助的临床学者研究计划，为精神病学居民在一个为期四年的研究培训轨道。其他活动将包括资助的多中心谱系收集和严重抑郁症和精神分裂症的基因组扫描;完成以前的精神分裂症基因组扫描项目;合作努力确定特定的易感基因;协调资助的项目，继续进行精神分裂症的多中心联系和关联研究;完成孤立人群心境障碍的数据收集，开发相关人群模拟软件和遗传分析策略。