Skin penetration and metabolism of a new micellar retinol formulation for cosmetics and therapeutics

用于化妆品和治疗的新型胶束视黄醇配方的皮肤渗透和代谢

• 批准号: ST/Y000560/1
• 负责人: Lian Liu
• 金额: $ 6.27万
• 依托单位: University of Surrey
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=ST%2FY000560%2F1
• 关键词: Skin; penetration; metabolism; new; micellar

The purpose of this study is to find out how Phytoceutical's nano-micellar retinol formulations work and how they impact the skin after use. To do this, we will use a special type of model that simulates the different layers of skin. This model will be exposed to ultraviolet (UV) light to simulate sun exposure before the Phyto formulations are applied.In the study, we will test three different concentrations of Phyto formulations (0.1%, 0.3%, and 1%) and compare the results to a standard retinol product and a control group where no product is applied.To observe the effects of the products on the skin model, we will use two types of special microscopes: light sheet microscopes and multiphoton microscopes. With the light sheet microscopes, we will examine how the product spreads in the skin model and how it affects the shape and position of the skin cells. With the multiphoton microscopes, we will see the effects of the product on the production of collagen, which is an important protein that helps keep skin looking youthful, and on the healing of wounds in the skin.We will also use two different spectroscopy techniques to track the conversion of retinol to retinoic acid, which is a process that occurs in the skin. This will give us information about whether the Phyto formulations are affecting this process and how they compare to the standard retinol product and the control group.By comparing the results of the Phyto formulations, the standard retinol product, and the control group, we will be able to determine the optimal concentration of Phyto formulations for use in skin care products. This information will be important for developing safe and effective products that can help people achieve healthier, more youthful-looking skin.

这项研究的目的是找出Phytoceutical的纳米胶束视黄醇配方如何工作，以及它们在使用后如何影响皮肤。为此，我们将使用一种特殊类型的模型来模拟不同的皮肤层。在使用Phyto配方之前，该模型将暴露在紫外线（UV）下以模拟阳光照射。在研究中，我们将测试三种不同浓度的Phyto配方（0.1%、0.3%和1%），并将结果与标准视黄醇产品和未施用产品的对照组进行比较。我们将使用两种类型的特殊显微镜：光片显微镜和多光子显微镜。使用光片显微镜，我们将检查产品如何在皮肤模型中扩散，以及它如何影响皮肤细胞的形状和位置。通过多光子显微镜，我们将观察产品对胶原蛋白（一种有助于保持皮肤年轻的重要蛋白质）的产生以及对皮肤伤口愈合的影响。我们还将使用两种不同的光谱技术来跟踪皮肤中发生的视黄醇转化为视黄酸的过程。这将为我们提供有关Phyto配方是否影响这一过程以及它们与标准视黄醇产品和对照组的比较情况的信息。通过比较Phyto配方、标准视黄醇产品和对照组的结果，我们将能够确定Phyto配方用于护肤品的最佳浓度。这些信息对于开发安全有效的产品非常重要，可以帮助人们获得更健康，更年轻的皮肤。