STRATEGIC STUDIES IN BREAST CANCER SURVEILLANCE

乳腺癌监测的战略研究

• 批准号: 6377854
• 负责人: PATRICIA A CARNEY
• 金额: $ 47.39万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2005-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6377854
• 关键词: breast neoplasms; cancer registry /resource; cancer risk; clinical research; cooperative study; data collection methodology /evaluation; diagnosis quality /standard; female; human subject; mammography; mathematical model; menstrual cycle; model design /development; neoplasm /cancer epidemiology; psychological aspect of cancer

The long term objective of this proposal is to enhance the New Hampshire Mammography Network's research capacity by expanding data collection to include determining outcomes in women who experienced mammographic abnormalities and whose subsequent breast outcomes are not recorded in our registry, determining what motivated women who experienced a false negative mammogram to obtain follow-up care, and collecting or merging supplemental data to allow us to conduct five special research projects. These special studies will include: 1) comparing risk and behavioral characteristics of screened and unscreened NH women; 2) determining the relationships between benign breast pathology characteristics and mammography performance; 3) exploring the influence of menstrual cycle phase on breast density and breast cancer screening performance; 4) developing risk prediction models for invasive and non-invasive breast cancer (including using breast density as a marker for breast cancer risk); and 5) using regression modeling techniques to develop a longitudinal model of mammography/health states defined by screening compliance, mammography outcomes, follow-up and disease outcomes in individual subjects and to determine predictors for transitions between these states, including an evaluation of mammography-related predictors for all cause mortality and breast-cancer mortality. Our proposed projects will benefit the work of the Breast Cancer Surveillance Consortium in two ways. First, determining sources of inadequate follow-up (whether it is a patient factor or data collection issue) will identify the capture rate of population-based mammography registries and may identify possible intervention points for those with abnormal findings who are resistant to seeking care. Second, we plan to merge data from three registries (New Hampshire, Vermont, and North Carolina) to conduct three of our study aims. By pooling data from these three registries, the number of cancer cases for analysis will be increased and the characteristics of the population represented in the data will be more diverse. Our specific aims can easily be addressed with data from the three proposed sites; however, any validation studies could apply well established methods from this proposed work to a larger dataset accessed from the Consortium in the future. Our aims will allow us to employ local analytic expertise while contributing new knowledge to the Surveillance Consortium.

该提案的长期目标是通过扩大数据收集范围来提高新罕布什尔州乳腺X线摄影网络的研究能力，以包括确定经历过乳腺X线摄影异常且随后的乳腺结果未记录在我们的登记研究中的女性的结果，确定是什么促使经历了假阴性乳腺X线摄影的女性获得随访护理，并收集或合并补充数据，使我们能够进行五个特殊的研究项目。这些特殊研究将包括：1）比较筛查和未筛查NH妇女的风险和行为特征; 2）确定良性乳腺病理特征和乳腺X线摄影表现之间的关系; 3）探索月经周期阶段对乳腺密度和乳腺癌筛查表现的影响; 4）开发侵袭性和非侵袭性乳腺癌的风险预测模型（包括使用乳腺密度作为乳腺癌风险的标志）;以及5）使用回归建模技术来开发由筛查依从性，乳房X线照相术结果，个体受试者的随访和疾病结局，并确定这些状态之间转换的预测因子，包括评估全因死亡率和乳腺癌死亡率的乳腺X线摄影相关预测因子。 我们提出的项目将在两个方面有利于乳腺癌监测联盟的工作。首先，确定随访不足的来源（无论是患者因素还是数据收集问题）将确定基于人群的乳腺X线摄影登记研究的捕获率，并可能为那些不愿寻求治疗的异常结果患者确定可能的干预点。 其次，我们计划合并三个登记中心（新罕布什尔州、佛蒙特州和北卡罗来纳州）的数据，以实现我们的三个研究目标。 通过汇总这三个登记中心的数据，将增加用于分析的癌症病例数量，数据中所代表的人群特征将更加多样化。 我们的具体目标可以很容易地从三个拟议的网站的数据解决;然而，任何验证研究可以应用完善的方法，从这个拟议的工作，以更大的数据集访问的联盟在未来。 我们的目标将使我们能够利用当地的分析专业知识，同时为监视联盟贡献新的知识。