ANTICARDIOLIPIN ANTIBODIES IN ANTIPHOSPHOLIPID SYNDROME

抗磷脂综合征中的抗心磷脂抗体

• 批准号: 6374981
• 负责人: POJEN P CHEN
• 金额: $ 25.17万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-02-25 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6374981
• 关键词: autoimmune disorder; biomimetics; cardiolipins; clinical research; diagnostic tests; enzyme linked immunosorbent assay; female; human subject; immunoglobulin G; immunopathology; laboratory mouse; monoclonal antibody; phospholipids; pregnancy loss; systemic lupus erythematosus; technology /technique development; thrombosis

DESCRIPTION: (Adapted from the Investigator's Abstract): Aim 1 is to generate and characterize 10 IgG monoclonal aCLs. Aim 2 is to analyze monoclonal aCLs in the in vivo fetal loss model. Aim 3 is to identify and characterize the mimetics for pathogenic aCL. Aim 4 is to do immunological and functional studies of antibodies against mimetics in APS patients. Aim 5 is to apply mimetics to study pathogenic aCL in APS patients and controls.

描述：（改编自研究者摘要）：目的1是生成 并鉴定了10个IgG单克隆aCL。目的2是分析单克隆aCL， 体内胎儿丢失模型。目的3是识别和表征 致病性aCL的模拟物。目的4是做免疫和功能 APS患者中抗模拟物抗体的研究。目标5：应用 研究APS患者和对照组中致病性aCL的模拟物。