ETS GENES AND TRANSFORMATION AND DIFFERENTIATION

ETS 基因以及转化和分化

• 批准号: 6376871
• 负责人: Dennis K Watson
• 金额: $ 104.46万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6376871
• 关键词: cell differentiation; cell growth regulation; genetic regulation; neoplasm /cancer genetics; transcription factor

The overall goal of this Program Project is to understand how the ets gene family functions in the regulation of cellular growth, differentiation and transformation. Family members play an important role in hematopoiesis, angiogenesis and vascular development. That the ets genes have a role in cancer was first suggested by the presence of ets sequences found in the oncogenic virus, E26. Family members are located in chromosomal regions associated with certain leukemias, Down Syndrome and retroviral induced cancers. The ets genes are transcriptional factors, have independent activities and are likely to constitute a fundamental integrated regulatory network. The precise interplay among the members of this network has not as yet been elucidated. Although considerable work has been done the individual family members, no coherent efforts have been made to fully understand the functional inter-relationships among the family members. This Program Project proposes to study the interplay among these genes, and the key questions to be addressed are, 1) why do the ets genes occur as a family? What are the functional redundancies among the family members? ii) what other regulatory proteins interact with each family member? Does each ets gene family member interact with unique or common proteins? iii) What are the target genes for each family member? Are these target genes regulated by single or multiple members of the ets family? iv) In what signal transduction pathway are the ets genes family members involved? v) What are the roles of ets family members in oncogenesis, tumor suppressor and aberrant development? This Program Project focuses on studies of ETS1 and FLI1 cloned and characterized extensively studied by the principal Investigator and his collaborating PI's. These genes are representatives of the entire ets gene family, and their study will expand our knowledge of the function of the entire family.

本项目的总体目标是了解ets基因是如何 家族在调节细胞生长、分化和 转型家庭成员在造血中起着重要作用， 血管生成和血管发育。ets基因在 癌症最初是由在大肠杆菌中发现的ets序列的存在提出的。 致癌病毒E26。家族成员位于染色体区域 与某些白血病，唐氏综合症和逆转录病毒诱导 癌的ets基因是转录因子，具有独立的 活动，并可能构成一个基本的综合 监管网络。这个组织的成员之间的相互作用 网络还没有被阐明。虽然大量的工作 家庭成员之间没有协调一致的努力， 充分了解各部门之间的职能相互关系， 家庭成员本计划项目建议研究以下方面的相互作用： 这些基因，以及要解决的关键问题是，1）为什么ETS 基因是一个家族吗这些机构之间的职能冗余是什么？ 家庭成员？（2）其他调节蛋白与之相互作用。 家庭成员？每个ets基因家族成员是否与独特的或 普通蛋白质？（3）每个家族成员的靶基因是什么？ 这些靶基因是由单个还是多个ets成员调控的 家人？iv）ets基因家族在什么样的信号转导通路中 成员参与？（五）ETS家庭成员在以下方面的作用： 肿瘤发生、肿瘤抑制和异常发育？这个程序 项目重点研究ETS1和FLI1的克隆和表征 由首席研究员和他的合作者广泛研究， 私家侦探。这些基因是整个ets基因家族的代表， 他们的研究将扩大我们对整个系统功能的认识。 家人