Biochemical and Behavioral Mechanisms of Toxicology

毒理学的生化和行为机制

• 批准号: 6314363
• 负责人: Jack A. Hinson
• 金额: $ 5.24万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314363
• 关键词: Biochemical; Behavioral; Mechanisms; Toxicology

DESCRIPTION (Provided by Applicant) The purpose of this proposed training program is to promote the development of toxicological sciences focusing on research in biochemical and behavioral toxicology at the University of Arkansas for Medical Sciences (UAMS) through an Institutional National Research Service Award. This will be accomplished through developing or extending the research skills and knowledge of pre-doctoral students and thereby prepare them for productive research careers. The Interdisciplinary Toxicology Graduate Program (INTOX) is a joint program between UAMS and the adjunct faculty at the National Center for Toxicological Research with students conducting their dissertation research at either institution. Also, the investigators have a Pharmacology training program (PHARM). Pre-doctoral students will be actively recruited and evaluated for admission to the graduate school on the basis of their GPA, GRE scores, letters of recommendation, and prior research experience. The pre-doctoral students will be supported by UAMS fellowships their first year. At the completion of their first year, students will be evaluated on their graduate school record, and most importantly, their performance in research rotations for participation on the training grant. The top two students will be offered support on the training grant and will be supported for years 2, 3, and 4 if they wish to specialize in biochemical and behavioral toxicology at UAMS. Their progress while on the training grant will be monitored by their participation in seminars, research and course work performance, authored manuscripts and abstracts, and annual reports. The toxicology training faculty who specialize in biochemical toxicology are: Hinson (hepato-, metabolic-, signal transduction), Schnellmann (nephro-, molecular, signal transduction), Jaeschke (hepato-, immuno-, signal transduction), Samokyszyn (metabolic-, oncology), Grant (molecular-, metabolic-), Owens (pharmacokinetic-, immuno-, metabolic-), Belcher (neuro, molecular), Wessinger (pharmacokinetic-), Prather (neuro-, signal transduction), Mayeux (nephro-, metabolic-, signal transduction), and Stimers (cardiovascular-). The faculty who specialize in behavioral toxicology include: McMillan, Wenger, Wessinger, Prather, and Owens. The faculty are well-funded and have an excellent track record of training graduate students. The facilities are excellent and the faculty are located in the Biomedical Research Center building. A current and future national need in toxicology is an understanding mechanisms of toxicity of chemicals at all levels, molecular through behavioral. By training students over this continuum the investigators will add a pool of toxicologists capable of addressing our national needs.

描述（申请人提供） 本培训计划的目的是促进 毒理学，侧重于研究生物化学和行为 毒理学在阿肯色州大学医学科学（UAMS）通过 国家研究服务机构奖。这将是完成 通过发展或扩大研究技能和知识的博士前 学生，从而为他们的生产研究生涯做好准备。 跨学科毒理学研究生课程（INTOX）是一个联合项目， UAMS和国家毒理学中心的兼职教师之间 研究与学生进行他们的论文研究，无论是在 机构。此外，研究人员还接受了药理学培训计划 （PHARM）.博士生预科将积极招募和评估， 根据他们的GPA，GRE成绩， 推荐信和先前的研究经验。博士预科 学生将在第一年获得UAMS奖学金的支持。在 完成第一年，学生将在他们的毕业评估 学校记录，最重要的是，他们在研究轮换中的表现 参加培训补助金。前两名的学生将获得 培训补助金的支持，并将支持第2年，第3年和第4年，如果 他们希望在UAMS专攻生物化学和行为毒理学。 他们在接受培训补助金期间的进展将由他们的 参加研讨会，研究和课程工作的表现，撰写 手稿和摘要以及年度报告。毒理学培训 专门从事生物化学毒理学的教师有：Hinson（肝， 代谢，信号转导），Schnellmann（肾，分子，信号 transduction），Jaeschke（hepato-，immuno-，signal transduction），Samokyszyn （代谢-，肿瘤学），格兰特（分子-，代谢-），欧文斯 （药代动力学、免疫、代谢）、Belcher（神经、分子）、Wessinger （药代动力学-），Prather（神经-，信号转导），Mayeux（肾-， 代谢-、信号转导）和刺激物（心血管-）。学院 专门研究行为毒理学的人包括：麦克米兰，温格，韦辛格， 普拉瑟和欧文斯学院资金充足， 培养研究生的记录。酒店的设施很好， 学院位于生物医学研究中心大楼。电流和 未来国家在毒理学方面的需要是了解毒性的机制 从分子到行为的各个层面的化学物质。通过培训 研究人员将在这一连续体中添加一个学生库， 有能力满足我们国家需求的毒理学家。