Biochemical and Behavioral Mechanisms of Toxicology

毒理学的生化和行为机制

• 批准号: 6498291
• 负责人: Jack A. Hinson
• 金额: $ 11.4万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6498291
• 关键词: Biochemical; Behavioral; Mechanisms; Toxicology

DESCRIPTION (Provided by Applicant) The purpose of this proposed training program is to promote the development of toxicological sciences focusing on research in biochemical and behavioral toxicology at the University of Arkansas for Medical Sciences (UAMS) through an Institutional National Research Service Award. This will be accomplished through developing or extending the research skills and knowledge of pre-doctoral students and thereby prepare them for productive research careers. The Interdisciplinary Toxicology Graduate Program (INTOX) is a joint program between UAMS and the adjunct faculty at the National Center for Toxicological Research with students conducting their dissertation research at either institution. Also, the investigators have a Pharmacology training program (PHARM). Pre-doctoral students will be actively recruited and evaluated for admission to the graduate school on the basis of their GPA, GRE scores, letters of recommendation, and prior research experience. The pre-doctoral students will be supported by UAMS fellowships their first year. At the completion of their first year, students will be evaluated on their graduate school record, and most importantly, their performance in research rotations for participation on the training grant. The top two students will be offered support on the training grant and will be supported for years 2, 3, and 4 if they wish to specialize in biochemical and behavioral toxicology at UAMS. Their progress while on the training grant will be monitored by their participation in seminars, research and course work performance, authored manuscripts and abstracts, and annual reports. The toxicology training faculty who specialize in biochemical toxicology are: Hinson (hepato-, metabolic-, signal transduction), Schnellmann (nephro-, molecular, signal transduction), Jaeschke (hepato-, immuno-, signal transduction), Samokyszyn (metabolic-, oncology), Grant (molecular-, metabolic-), Owens (pharmacokinetic-, immuno-, metabolic-), Belcher (neuro, molecular), Wessinger (pharmacokinetic-), Prather (neuro-, signal transduction), Mayeux (nephro-, metabolic-, signal transduction), and Stimers (cardiovascular-). The faculty who specialize in behavioral toxicology include: McMillan, Wenger, Wessinger, Prather, and Owens. The faculty are well-funded and have an excellent track record of training graduate students. The facilities are excellent and the faculty are located in the Biomedical Research Center building. A current and future national need in toxicology is an understanding mechanisms of toxicity of chemicals at all levels, molecular through behavioral. By training students over this continuum the investigators will add a pool of toxicologists capable of addressing our national needs.

描述（由申请人提供） 该建议的培训计划的目的是促进 毒理学专注于生化和行为研究 阿肯色大学医学科学（UAMS）的毒理学通过 机构国家研究服务奖。这将完成 通过发展或扩展研究技能和知识 学生，从而为他们的生产研究职业做好准备。 跨学科毒理学研究生计划（INX）是一个联合计划 在美国国家毒理学中心的UAM和兼职教师之间 与学生进行论文研究的研究 机构。此外，调查人员还有一个药理学培训计划 （Pharm）。博士前的学生将被积极招募和评估 根据他们的GPA，GRE得分，入学 推荐信和先前的研究经验。前博士 第一年将获得UAMS奖学金的支持。在 完成第一年的完成，将对学生的研究生进行评估 学校记录，最重要的是，他们在研究轮换方面的表现 参加培训补助金。将提供前两个学生 支持培训补助金，如果2、3和4的支持，如果 他们希望在UAMS专门研究生化和行为毒理学。 他们在培训赠款中的进步将由他们的 参加研讨会，研究和课程工作表现 手稿和摘要以及年度报告。毒理学培训 专门从事生化毒理学的教师是：Hinson（Hepato-， 代谢，信号转导），schnellmann（肾脏，分子，信号 转导），Jaeschke（hepato-，Immuno-，信号转导），Samokyszyn （代谢 - 肿瘤学），授予（分子 - ，代谢），欧文斯 （药代动力学，免疫，代谢 - ），贝尔彻（Neuro，分子），Wessinger （药代动力学 - ），Prather（神经，信号转导），Mayeux（Nephro-， 代谢，信号转导）和刺激器（心血管 - ）。教师 专门从事行为毒理学的人包括：麦克米伦，温格，韦森格， Prather和Owens。该教师资金充足，轨道很棒 培训研究生的记录。设施很棒， 教师位于生物医学研究中心大楼。电流和 毒理学未来的国家需求是一种毒性的理解机制 各级化学物质，通过行为分子。通过培训 在这个连续体中，调查人员将添加一个池 毒理学家能够满足我们的国家需求。