DEVELOPMENTAL EPIDEMIOLOGY OF ANXIETY IN PRESCHOOLERS

学龄前儿童焦虑的发展流行病学

• 批准号: 6490788
• 负责人: HELEN L. EGGER
• 金额: $ 16.43万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-16 至 2005-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6490788
• 关键词: age difference; anxiety; anxiety disorders; behavioral /social science research tag; behavioral genetics; developmental psychology; diagnosis design /evaluation; disease /disorder etiology; disease /disorder proneness /risk; family structure /dynamics; gene environment interaction; human subject; interview; mental disorder diagnosis; mental health epidemiology; middle childhood (6-11); parent offspring interaction; patient oriented research; pediatrics; preschool child (1-5); psychological stressor; psychometrics; questionnaires; statistics /biometry; twin /multiplet

The purpose of this Mentored Patient-Oriented Research Career Development Award (K23) is to enable the candidate, a child psychiatrist, to became an independent research investigating the development pathways and causes of anxiety disorders in preschool children. The research goal is to place preschoolers' anxiety symptoms and disorders within the framework of developmental epidemiology by focusing on two questions: 1. What are the age-specific presentations of anxiety disorders in children ages 2 to 5 years old? (Nosology) 2. What are the relative contributions of genes and environment and their interaction in the early development of anxiety disorders? (etiology). This application details a program of training in infant/young child psychiatry, in behavioral and statistical genetics with an introduction to molecular genetics and genomics, and advanced training in pediatric anxiety disorders. The candidate is based in the Center for Developmental Epidemiology, Duke University Medical Center. Sponsors are child psychiatrists Adrian Angold MRCPsych (developmental psychopathology and measure development), Robert Emde MD, and Charles Zeanah MH (infant/young child psychiatry and assessment of young children), and John March MD (anxiety disorders). Lindon Eaves PhD, a leading behavioral geneticist, will provide mentoring in this area. The research plan includes: 1. A detailed review of current instrumentation for assessing preschool anxiety. 2. A pilot study of 60 children aged 36-72 months, using a multi-informant assessment protocol. DSM-IV and DC:0-3 diagnoses and symptoms will be assessed using the Preschool Age Psychiatric Assessment (PAPA), a structured parent interview developed by the candidate. 3. Analysis of data on 15,500 2-5 year-old twin pairs to examine the contributions of genes and shared and non-shared environmental factors to young children's anxiety symptoms. 4. Submission of an R01 application for a longitudinal, genetically-informed study of the development of anxiety disorders in preschool children. This work will make important contributions to the development of prevention and treatment interventions for young children and will contribute to our understanding of the etiology of childhood psychopathology.

这个指导以病人为导向的研究职业发展奖（K23）的目的是使候选人，儿童精神病学家，成为一个独立的研究调查的发展途径和学龄前儿童焦虑症的原因。本研究的目的是将学龄前儿童的焦虑症状和障碍置于发展流行病学的框架内，重点关注两个问题：1。2 - 5岁儿童焦虑症的年龄特异性表现是什么？（疾病分类学）2.基因和环境及其相互作用在焦虑症早期发展中的相对贡献是什么？（病因学）。该申请详细介绍了婴儿/幼儿精神病学培训计划，行为和统计遗传学，介绍分子遗传学和基因组学，以及儿科焦虑症的高级培训。候选人在杜克大学医学中心的发育流行病学中心工作。发起人是儿童精神病学家Adrian Angold MRCPsych（发展精神病理学和测量发展），Robert Emde MD和Charles Zeanah MH（婴儿/幼儿精神病学和幼儿评估）以及John March MD（焦虑症）。林登屋檐博士，一个领先的行为遗传学家，将提供这方面的指导。研究计划包括：1.详细回顾目前的仪器评估学龄前焦虑。2.一项针对60名36-72个月大的儿童的试点研究，采用多信息人评估协议。DSM-IV和DC：0-3诊断和症状将使用学龄前精神病评估（PAPA）进行评估，这是一种由候选人开发的结构化父母访谈。3.对15,500对2-5岁双胞胎的数据进行分析，以检查基因以及共享和非共享环境因素对幼儿焦虑症状的贡献。4.提交R 01申请，以进行学龄前儿童焦虑症发展的纵向遗传学研究。这项工作将作出重要贡献，为幼儿的预防和治疗干预措施的发展，并将有助于我们了解儿童精神病理学的病因。