TREATING CHINESE SMOKERS WITH INTERACTIVE EXPERT SYSTEMS

利用交互式专家系统治疗中国吸烟者

• 批准号: 6523137
• 负责人: Janice Y Tsoh
• 金额: $ 13.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-16 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6523137
• 关键词: Chinese American; clinical research; computer assisted patient care; culture; depression; gender difference; human subject; human therapy evaluation; interactive multimedia; racial /ethnic difference; smoking; smoking cessation; statistics /biometry; tobacco abuse

This K23 mentored patient-oriented research application will support the career development of the candidate in the area of nicotine dependence and tobacco control, particularly targeting smoking cessation efforts to the ethnic minority populations. Drs. Sharon Hall and Neal Benowitz of the University of California, San Francisco will serve as the primary and secondary mentors. The objective for this 5-year proposed program is to provide training and hands-on experience in designing and conducting clinical trials, cross-cultural research and methodology, and clinical pharmacology knowledge and applications. The overall goal of this research is to design and test efficacious smoking cessation programs that can successfully treat a large minority group, Chinese American smokers. This study will transfer the interactive expert system technology in smoking cessation to Chinese American smokers and test the efficacy of the intervention using a randomized clinical trial in this population. It will also examine the effectiveness of proactive versus reactive recruitment approaches, which will guide implementation of smoking cessation intervention in this population. Participants will be randomized to either to a control condition receiving a standard self-help manual, or experimental condition receiving a stage-matched manual and 3 personalized expert-system reports over 6 months. Assessments will occur before randomization at baseline, 3, 6, 12, and 18 months. It is hypothesized that research participants receiving the experimental smoking cessation intervention will be more likely to be abstinent, report at least one quit attempt, and to significantly reduce in smoking rate (verified by continine) than those in the control condition at 12 and 18 months. The proactive recruitment approach is hypothesized to be more effective in reaching smokers who are not ready to quit smoking. Depression symptoms, negative affect, acculturation and gender differences in association with smoking behaviors and nicotine dependence in the Chinese population will be examined. Pilot work focusing on enhancing smoking intervention for this population will be conducted based on the findings of the proposed clinical trial. This research and career development program will yield significant knowledge for effectively treating Chinese American smokers, and will build a solid foundation to prepare the candidate to be an independent clinical research scientist.

这种K23指导的以患者为导向的研究应用程序将支持候选人在尼古丁依赖和烟草控制领域的职业发展，特别是针对少数民族人群的戒烟工作。加州大学旧金山分校弗朗西斯科的莎伦·霍尔博士和尼尔·本诺维茨博士将担任初级和次级导师。 这个为期5年的拟议计划的目标是提供设计和进行临床试验，跨文化研究和方法以及临床药理学知识和应用方面的培训和实践经验。 这项研究的总体目标是设计和测试有效的戒烟计划，可以成功地治疗一个大的少数群体，华裔美国吸烟者。 本研究将把交互式专家系统戒烟技术应用于美国华裔吸烟者，并在该人群中进行随机临床试验，以检验干预的有效性。 它还将检查主动与被动招募方法的有效性，这将指导在这一人群中实施戒烟干预。 参与者将被随机分配到接受标准自助手册的对照条件或接受阶段匹配手册和3个个性化专家系统报告的实验条件，为期6个月。 将在基线、3、6、12和18个月随机化前进行评估。 假设接受实验性戒烟干预的研究参与者在12个月和18个月时比对照组更有可能戒烟，报告至少一次戒烟尝试，并显著降低吸烟率（通过continine验证）。 据推测，主动招募方法在接触尚未准备好戒烟的吸烟者方面更有效。将研究中国人群中抑郁症状、负性情感、文化适应和性别差异与吸烟行为和尼古丁依赖的关系。 我们会根据拟议临床试验的结果，进行先导工作，集中加强对这类人士的吸烟干预。 这项研究和职业发展计划将为有效治疗华裔美国吸烟者提供重要的知识，并为候选人成为独立的临床研究科学家奠定坚实的基础。