A genomic and chemogenomic approach to the protein quality control problem

战略研究重点：健康生物科学蛋白质质量控制对细胞健康至关重要。蛋白质质量控制缺陷是多种疾病的基础，并与衰老过程密切相关。本研究的目的是描述在系统水平上调节和调节蛋白质质量控制的过程，并确定新的化学调节剂。该项目将结合酵母微哺乳动物Schizosaccharomyces pombe的遗传易变性与哺乳动物细胞生物学和脊椎动物斑马鱼模型，为调节这一过程的网络和途径提供非常详细的了解，并为其研究提供新的工具。

Strategic Research Priority: Bioscience for HealthProtein quality control is vital to cellular health. Defects in protein quality control underlie a broad range of diseases, and are closely linked to the ageing process. The aim of this study is to describe the processes that regulate and modulate protein quality control at a systems-level and to identify new chemical modulators. The project will combine the genetic tractability of the yeast micromammal Schizosaccharomyces pombe with mammalian cell biology and a vertebrate zebrafish model, providing a highly detailed understanding of the networks and pathways that regulate this process, and new tools for its study.