CORE--DATA COORDINATION

结节病是一种病因不明的全身性肉芽肿性疾病，可能与遗传易感宿主中的某些环境因素有关。我们建议确定结节病的易感基因，并确定这些基因和环境风险因素如何相互作用而导致结节病。这将通过组织一个多中心财团招募足够的结节病家系样本进行分析来实现。我们计划使用影响同胞对连锁分析来扫描基因组以寻找相连的染色体区域，传递不平衡检验来评估那些具有连锁证据的区域中的候选基因，并使用环境问卷来收集数据来测试易感基因与外源性危险因素可能的相互作用。该应用程序提供生物统计和研究流行病学部门，Henry Ford Health System作为该项目的数据协调中心(DCC)。数据中心将提供行政协调，编写研究文件，制定招聘战略，提供研究跟踪，建立中央数据库，进行数据质量保证，并与联盟其他成员合作分析研究结果。数据协调中心(DCC)将是联合体内的一个独立单位，并将接受指导委员会的指导。DCC团队由首席研究员Sarah Fowler博士领导，她是一名资深生物统计学专家，专门负责协调中心的多中心研究，协调中心生物统计学家兼Co-Pi Mei Lu博士将担任DCC的项目经理。DCC联合调查员Marvella Ford博士将就招募和保留非裔美国人受试者及其家人向合作小组提供建议。协调中心团队还包括一支由个人(程序员、数据协调员和秘书)组成的支持人员，他们在多中心研究方法方面经验丰富并致力于此。

Sarcoidosis is a systemic granulomatous disease of unknown etiology that likely involves exposure to some environmental agent in a genetically susceptible host. We propose to identify sarcoidosis susceptibility genes and determine how these genes and environmental risk factors interact to cause sarcoidosis. This will be accomplished by organizing a multicenter consortium to recruit an adequate sample of sarcoidosis families for analysis. We plan to use affecting sibling pair linkage analysis to scan the genome for linked chromosomal regions, transmission disequilibrium testing to evaluate candidate genes in those regions with evidence for linkage and an environmental questionnaire to collect data to test for possible interactions of susceptibility genes with exogenous risk factors. This application offers the Department of Biostatistics and Research Epidemiology, Henry Ford Health System as the Data Coordinating Center (DCC) for the project. The DCC will provide administrative coordination, develop study documents, develop recruitment strategies, provide study tracking, establish a central data base, conduct data quality assurance, and collaborate with other members of the consortium in analysis of the results of the study. The Data Coordinating Center (DCC) will be an independent unit within the consortium, and will take guidance from the Steering Committee. The DCC team is headed by Principal Investigator Sarah Fowler, PhD, a senior biostatistical who specializes in coordinating centers for multi-center studies, and coordinating center biostatistician and Co-PI Mei Lu, PhD, who will sere as project manger for the DCC. DCC Co-Investigator Marvella Ford, PhD, will advise the collaborative group on the recruitment and retention of African American subjects and their families. The Coordinating Center team also includes a support staff consisting of individuals (programmer, data coordinator and secretary) experienced in and dedicated to methodologies for multi-center studies.