PIOPED II-DATA COORDINATING CENTER

PIOPED II 数据协调中心

基本信息

  • 批准号:
    6402779
  • 负责人:
  • 金额:
    $ 50.69万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-09-01 至 2004-07-31
  • 项目状态:
    已结题

项目摘要

This is a multi-center collaborative study to determine the sensitivity, specificity, positive predictive value, and negative predictive value of contrast enhanced spiral computed tomography (spiral CT) for the diagnosis of acute pulmonary embolism (PE). Pulmonary embolism is common, yet frequently undiagnosed and fatal. Ventilation/perfusion scan is the most frequently used test, but is non-diagnostic in 72 percent of patients with suspected PE, and in 57 percent of patients with proven PE. Pulmonary angiography is the currently definitive diagnostic test, but there is hesitancy to use it because of morbidity,' discomfort, cost, and lack of availability in community hospitals. Contrast enhanced spiral CT is a nearly noninvasive test that offers the possibility of a definitive diagnosis of PE by showing the outline of the thrombus in a pulmonary artery. However, its utility in the diagnosis of PE is unknown. Even though spiral CT has not been adequately validated, many physicians now use it as a definitive and only diagnostic test for PE, or as a definitive test in patients in whom the ventilation/perfusion lung scan is non-diagnostic. This could lead to over treatment or under treatment, and potential serious complications. The role of spiral CT in the diagnosis of PE requires the accurate evaluation that will be made in this investigation. In response to reviewer suggestions on the original application, this revised application proposes to use a composite reference standard based on ventilation / perfusion lung scan, compression ultrasound of the lower extremities, and angiography. The strengths of the proposal are: 1) the importance of the problem of PE in terms of lives lost from under diagnosis, and major bleeding from over diagnosis; 2) the potential applicability of a new technology for the diagnosis of PE that will have widespread availability; and 3) the investigator team.
这是一项多中心协作研究,旨在确定对比增强螺旋计算机断层扫描(螺旋CT)诊断急性肺栓塞(PE)的敏感性、特异性、阳性预测值和阴性预测值。肺栓塞是常见的,但往往无法诊断和致命的。 通气/灌注扫描是最常用的检查,但在72%的疑似PE患者和57%的确诊PE患者中不能诊断。肺血管造影是目前最确定的诊断测试,但由于发病率,不适,成本和社区医院缺乏可用性,使用它犹豫不决。 对比增强螺旋CT是一种几乎无创的检查,通过显示肺动脉血栓的轮廓,为PE的明确诊断提供了可能性。然而,其在PE诊断中的效用尚不清楚。 尽管螺旋CT尚未得到充分验证,但许多医生现在将其用作PE的确定性和唯一诊断测试,或用作通气/灌注肺扫描无法诊断的患者的确定性测试。 这可能导致过度治疗或治疗不足,以及潜在的严重并发症。 螺旋CT在PE诊断中的作用需要在本研究中做出准确的评价。 为响应审评员对原始申请的建议,本修订申请建议使用基于通气/灌注肺扫描、下肢压迫超声和血管造影的复合参考标准。 该提案的优势在于:1)PE问题的重要性,即因诊断不足而导致的生命损失,以及过度诊断导致的大出血; 2)一种新技术在PE诊断中的潜在适用性,该技术将具有广泛的可用性;以及3)研究者团队。

项目成果

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Sarah E. Fowler其他文献

Quantitative and qualitative changes in lipids, lipoproteins, apolipoprotein A‐I, and sex hormone‐binding globulin due to two doses of conjugated equine estrogen with and without a progestin
两剂含和不含孕激素的结合马雌激素导致脂质、脂蛋白、载脂蛋白 A-I 和性激素结合球蛋白的定量和定性变化
  • DOI:
    10.1016/0020-7292(94)90487-1
  • 发表时间:
    1994
  • 期刊:
  • 影响因子:
    3.8
  • 作者:
    Valery T. Miller;R. Muesing;John C. LaRosa;D. B. Stoy;Sarah E. Fowler;Robert J. Stillman
  • 通讯作者:
    Robert J. Stillman
Towards the development of the psychosocial impact of assistive devices scale for continence (C-PIADS)
制定失禁辅助器具的社会心理影响量表(C-PIADS)
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Adele Long;K. Southall;Sarah E. Fowler;N. Cotterill;E. Heuvel;J. Jutai
  • 通讯作者:
    J. Jutai

Sarah E. Fowler的其他文献

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{{ truncateString('Sarah E. Fowler', 18)}}的其他基金

Diabetes Prevention Program Outcomes Study
糖尿病预防计划成果研究
  • 批准号:
    7980504
  • 财政年份:
    2009
  • 资助金额:
    $ 50.69万
  • 项目类别:
Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)
肺栓塞诊断前瞻性调查 III (PIOPED III)
  • 批准号:
    7236591
  • 财政年份:
    2005
  • 资助金额:
    $ 50.69万
  • 项目类别:
Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)
肺栓塞诊断前瞻性调查 III (PIOPED III)
  • 批准号:
    7499661
  • 财政年份:
    2005
  • 资助金额:
    $ 50.69万
  • 项目类别:
Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)
肺栓塞诊断前瞻性调查 III (PIOPED III)
  • 批准号:
    6956956
  • 财政年份:
    2005
  • 资助金额:
    $ 50.69万
  • 项目类别:
Prospective Investigation of Pulmonary Embolism Diagnosis III (PIOPED III)
肺栓塞诊断前瞻性调查 III (PIOPED III)
  • 批准号:
    7107185
  • 财政年份:
    2005
  • 资助金额:
    $ 50.69万
  • 项目类别:
CORE--DATA COORDINATION
核心——数据协调
  • 批准号:
    6631288
  • 财政年份:
    2002
  • 资助金额:
    $ 50.69万
  • 项目类别:
CORE--DATA COORDINATION
核心——数据协调
  • 批准号:
    6455810
  • 财政年份:
    2001
  • 资助金额:
    $ 50.69万
  • 项目类别:
PIOPED II-DATA COORDINATING CENTER
PIOPED II 数据协调中心
  • 批准号:
    6527268
  • 财政年份:
    2000
  • 资助金额:
    $ 50.69万
  • 项目类别:
PIOPED II-DATA COORDINATING CENTER
PIOPED II 数据协调中心
  • 批准号:
    6667156
  • 财政年份:
    2000
  • 资助金额:
    $ 50.69万
  • 项目类别:
PIOPED II-DATA COORDINATING CENTER
PIOPED II 数据协调中心
  • 批准号:
    6190351
  • 财政年份:
    2000
  • 资助金额:
    $ 50.69万
  • 项目类别:
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