FAMILY BLOOD PRESSURE PROGRAM

家庭血压计划

• 批准号: 6593352
• 负责人: NICHOLAS Joseph SCHORK
• 金额: $ 14.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-29 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6593352
• 关键词: blood pressure; cardiovascular disorder epidemiology; clinical research; cooperative study; data management; family genetics; genetic polymorphism; genetic susceptibility; genotype; heart disorder; human genetic material tag; human subject; hypertension; kidney disorder; linkage mapping; phenotype; statistics /biometry

The NHLBI Family Blood Pressure Program is made up of four cooperating networks whose overall objective is to localize and characterize genes contributing to variation in blood pressure levels and hypertension status. The four networks were originally separately funded and competitive, but two critical realizations have led to full cooperation and collaboration. First, the oligogenic nature of blood pressure control dictates that large samples are necessary to achieve adequate statistical power for genomic linkage and association analyses. Second, linkage intervals are broad and contain large numbers of genes, so that success in identifying genes and mutations requires the effort of multiple laboratories freely sharing information. This coordination extends far beyond phenotyping and genotyping and is best exemplified by the Program's creation of a pooled data set and agreements about coordinated publications. During the initial funding period, the Program surpassed its original recruitment goals, carried out multiple genome-wide linkage and association analyses and created an interim pooled data set consisting of phenotype and genotype data from more than 10,000 individuals. In this renewal application, the Program proposes five specific aims to be carried out by all four networks. These aims can be grouped according to two complementary themes: First, these applicants will create and analyze a database of blood pressure- related phenotype and genotype data from all FBPP participants (Aim 1). Within linked regions, they will identify allelic variation within positional candidate genes and evaluate the relationship of these polymorphisms with blood pressure levels and hypertension status (Aims 2 and 3). Second, they will use quantitative measures of target organ damage to identify genes that influence susceptibility to develop hypertensive heart and kidney diseases (Aims 4 and 5). In addition to the Program specific aims, each network proposes specific aims to be carried out by that network alone, based on unique aspects of their population and interests and expertise of the investigators. The Family Blood Pressure Program represents the most determined multidisciplinary approach to the genetics of hypertension ever assembled. The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk.

NHLBI家庭血压计划由四个合作伙伴组成。 其总体目标是定位和表征基因的网络 导致血压水平和高血压状态的变化。 这四个网络最初是分开供资和竞争的，但两个 重要的认识促成了充分的合作与协作。 第一、 血压控制的寡基因性质决定了大样本 是必要的，以实现足够的统计能力的基因组连锁， 关联分析 二是联动区间宽，包含大 因此，成功识别基因和突变需要 多个实验室自由共享信息的努力。 这 协调远远超出了表型和基因型， 例如，该计划创建了一个汇集的数据集和协议， 协调出版物。 在最初的资助期间，该计划超过了其最初的 招募目标，进行了多个全基因组的连锁和关联 分析并创建了一个中期合并数据集，包括表型和 超过10，000个个体的基因型数据。 在这次更新申请中， 该计划提出了五个具体目标，要求所有四个国家都实现 网络. 这些目标可按两个相辅相成的主题归类： 首先，这些申请人将创建和分析血压数据库- 所有FBPP参与者的相关表型和基因型数据（目标1）。 在连锁区域内，他们将识别位置内的等位基因变异， 候选基因，并评估这些多态性与 血压水平和高血压状态（目标2和3）。 二是 将使用靶器官损伤的定量测量来识别基因， 影响高血压心肾疾病易感性 (Aims第4和第5段）。 除了该方案的具体目标外，每个网络 建议由该网络单独实现的具体目标， 人口的独特方面以及联合国的利益和专长 investigators. 家庭血压计划代表了最坚定的 多学科方法的遗传学高血压以往任何时候都组装。 由此产生的综合思想和积累的数据允许严格的假设 测试不可能，否则将加快理解以前的 难以捉摸的遗传变异导致疾病风险。