THE SLEEP HEART HEALTH STUDY

睡眠心脏健康研究（SHHS）始于1994年，是一项多中心队列研究，旨在研究睡眠呼吸障碍（SDB）对心血管的影响。该研究的主要目的是评估SDB作为不良心血管结局的危险因素，包括冠心病事件、中风和高血压，以及随着年龄的增长血压加速升高。SHHS方案在正在进行的心血管和其他疾病的队列研究中增加了SDB的评估，包括Framingham Offspring和Omni队列，Hagerstown和Minneapolis/St。社区动脉粥样硬化风险（AMC）研究的Paul站点，心血管健康研究（CHS）的黑格斯敦、萨克拉门托和匹兹堡站点，南达科他州、俄克拉何马州和亚利桑那州的强心脏研究（SHS）站点，图森的呼吸系统疾病和纽约的高血压队列研究。在最初的四年（1994-1998）中，SHHS成功启动，从6,440名参与者家中获得了完整和高质量的多导睡眠图（PSG）数据，超出了招募目标。SHHS队列包括3039名男性和3401名女性，年龄在40岁或以上，其中8.2%是非洲裔美国人，9.6%是美洲原住民，1.3%是亚洲人，4.2%是西班牙裔。除PSG外，数据收集还包括打鼾、嗜睡和生活质量（QOL）。所有队列都制定了结果评估方案，目前正在进行第二次SHHS检查。初步横断面研究结果显示，SDB很常见，与高血压和自报心血管疾病（CVD）有关。这项申请需要五年的额外支持，以继续执行SHHS。需要进一步的随访以有足够的能力来检验SHHS的主要假设。此外，在8-9年级，将重复PSG，以进一步描述参与者的SDB特征，并描述SDB的自然历史。在最初的五年里，SHHS已经表明，可以在社区中进行关于睡眠、SDB和疾病风险的大规模研究。SHHS队列的随访将提供表征SDB心血管后果及其自然史所需的数据。本提案是为SHHS的亚利桑那大学领域中心提供资金的请求，以履行其在该多中心研究中对909名参与者进行重复PSG和心血管随访的作用。

The Sleep Heart Health Study (SHHS) was started in 1994 as a multicenter cohort study of the cardiovascular consequences of sleep-disordered breathing (SDB). The study's principal aims are to assess SDB as a risk factor for adverse cardiovascular outcomes, including incident coronary heart disease events, stroke, and hypertension, and accelerated increase in blood pressure with age. The SHHS protocol added an assessment of SDB to ongoing cohort studies of cardiovascular and other diseases, including the Framingham Offspring and Omni cohorts, the Hagerstown and Minneapolis/St. Paul sites of the Atherosclerosis Risk in Communities (AMC) Study, the Hagerstown, Sacramento, and Pittsburgh sites of the Cardiovascular Health Study (CHS), the Strong Heart Study (SHS) sites in South Dakota, Oklahoma, and Arizona, and cohort studies of respiratory disease in Tucson and of hypertension in New York. During its first four years (1994-1998), the SHHS was successfully started with full and high quality polysomnography (PSG) data obtained in the home from 6,440 participants, exceeding the recruitment target. The SHHS cohort, includes 3,039 men and 3,401 women 40 years of age or more, of whom 8.2 percent are African American, 9.6 percent are Native American, 1.3 percent are Asian, and 4.2 percent are Hispanic. In addition to PSG, data collection covered snoring and sleepiness and quality of life (QOL). Outcome assessment protocols are in place for all cohorts and the second SHHS examination is now in progress. Initial cross-sectional findings show that SDB is common and associated with hypertension and self-reported cardiovascular disease (CVD). This application requests five years additional support to continue the SHHS. Further follow-up is needed to have sufficient power to test the primary SHHS hypotheses. Additionally in Years 8-9, PSG will be repeated to further characterize SDB in the participants and to describe the natural history of SDB. During the first five years, the SHHS has shown that large-scale research on sleep, SDB, and disease risk can be conducted in the community. Follow-up of the SHHS cohort will provide the data needed to characterize the cardiovascular consequences of SDB, along with its natural history. This proposal is a request to fund the University of Arizona Field Center of the SHHS to fulfill its role performing repeat PSG and cardiovascular follow-up of 909 participants in this multicenter study.