Finding a Research Path for the Identification of Biomarkers of Sleepiness

寻找识别嗜睡生物标志物的研究途径

• 批准号: 8006185
• 负责人: STUART F. QUAN
• 金额: $ 2万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006185
• 关键词: Area; Biological Markers; Boston; Clinical Research; Development; Genomics; Industry; International; Journals; Link; Medicine; Molecular; Participant; Pathway interactions; Proteomics; PubMed; Public Health; Publishing; Research; Research Personnel; Sleep; Sleep Deprivation; Techniques; health economics; indexing; instrument; interest; medical schools; meetings; molecular marker; public health relevance; symposium; tool; web site

DESCRIPTION (provided by applicant): The conference, "Finding a Research Path for the Identification of Biomarkers of Sleepiness" will be a 1.5 meeting of world-renown experts in sleep deprivation research, proteomics, genomics and related fields who are being convened to discuss what is known concerning potential biomarkers of sleepiness and to develop a research pathway towards identifying clinically and research usable biomarkers of sleepiness. To these ends, the objectives of this conference are the following: 1. Provide an overview of the utility of current instruments to detect and quantify levels of sleepiness including both subjective and objective tools or techniques; 2. Present current research on the use of genomic, proteomic and molecular approaches to assess sleepiness with the emphasis on how such techniques might be used clinically or for clinical research; 3. Stimulate research into the development of clinically useful biomarkers of sleepiness by formulating a research pathway for investigators to follow. The conference will be sponsored by the Harvard Medical School, Division of Sleep Medicine and held on September 21-22, 2010 in Boston, MA. During these 1.5 days, international and national scholars will give presentations and participate in panel discussions focused in 3 areas: 1) Current Instruments to Assess Sleepiness; 2) Genomic, Proteomic and Molecular Markers of Sleepiness; and 3) Developing a Biomarker of Sleepiness. We expect to have an audience of approximately 100 participants consisting of a cross-disciplinary mixture of senior and more junior investigators, sleep researchers and investigators from other fields, and interested parties from industry. The proceedings will be published in a journal indexed in PubMed and a link to the proceedings will be posted on the Division of Sleep Medicine website. PUBLIC HEALTH RELEVANCE: The conference on "Finding a Research Path for the Identification of Biomarkers of Sleepiness" will be held on September 21-22, 2009 in Boston, MA. The overall objective of this conference is to develop research pathways for investigators to follow so that a clinically and research useful biomarker to quantify and detect sleepiness can be developed. Such a biomarker will have important utility in reducing the public health and economic consequences of sleepiness.

描述（由申请人提供）： 会议，“寻找一个研究路径的嗜睡的生物标志物的识别”将是一个1.5世界知名的专家在睡眠剥夺研究，蛋白质组学，基因组学和相关领域的会议，他们正在召集讨论什么是已知的关于潜在的嗜睡的生物标志物，并制定一个研究路径，以确定临床和研究有用的嗜睡的生物标志物。为此，本次会议的目标如下：1。概述当前检测和量化嗜睡水平的工具的效用，包括主观和客观工具或技术; 2.介绍目前使用基因组学、蛋白质组学和分子学方法评估嗜睡的研究，重点是这些技术如何在临床上使用或用于临床研究;通过制定研究路径供研究人员遵循，刺激对临床有用的嗜睡生物标志物的研究。会议将由哈佛医学院睡眠医学部主办，于2010年9月21日至22日在马萨诸塞州波士顿举行。在这一天半的时间里，国际和国内学者将发表演讲并参加小组讨论，重点关注3个领域：1）评估嗜睡的现有工具; 2）嗜睡的基因组，蛋白质组和分子标记; 3）开发嗜睡的生物标记。我们预计将有大约100名参与者，包括高级和初级研究人员，睡眠研究人员和其他领域的研究人员以及行业相关方的跨学科混合。会议记录将在PubMed索引的期刊上发表，会议记录的链接将在睡眠医学部网站上发布。 公共卫生关系： 关于“寻找嗜睡生物标志物识别的研究路径”的会议将于2009年9月21日至22日在马萨诸塞州波士顿举行。本次会议的总体目标是为研究人员开发研究途径，以便开发一种临床和研究有用的生物标志物来量化和检测嗜睡。这种生物标志物将在减少嗜睡的公共健康和经济后果方面具有重要的实用性。

项目成果

Finding a research path for the identification of biomarkers of sleepiness.

寻找识别嗜睡生物标志物的研究路径。

• DOI: 10.5664/jcsm.1338
• 发表时间: 2011
• 期刊: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
• 作者: Quan,StuartF

Association of inflammatory markers with cardiovascular risk and sleepiness.

炎症标志物与心血管风险和嗜睡的关联。

• DOI: 10.5664/jcsm.1356
• 发表时间: 2011
• 期刊: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
• 作者: Miller,MichelleA

New technologies for integrating genomic, environmental and trait data.

整合基因组、环境和性状数据的新技术。

• DOI: 10.5664/jcsm.1362
• 发表时间: 2011
• 期刊: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
• 作者: Church,GeorgeM

Potential of proteomics as a bioanalytic technique for quantifying sleepiness.

蛋白质组学作为量化睡意的生物分析技术的潜力。

• DOI: 10.5664/jcsm.1354
• 发表时间: 2011
• 期刊: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
• 作者: Naidoo,Nirinjini

Panel discussion: can there be a biomarker for sleepiness?

小组讨论：是否有困倦的生物标志物？

• DOI: 10.5664/jcsm.1364
• 发表时间: 2011
• 期刊: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
• 作者: Quan,StuartF;Shaw,PaulJ;Naidoo,Nirinjini;Haeggström,Edward;Krueger,JamesM;Church,GeorgeM
• 通讯作者: Church,GeorgeM