ULTRASONIC BLOOD VISCOMETER
超声波血液粘度计
基本信息
- 批准号:6294082
- 负责人:
- 金额:$ 9.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-03-01 至 2002-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
DESCRIPTION (Verbatim from Applicant's Abstract): Blood viscosity is altered in
diseases such as sickle cell anemia, hypertension, and atherosclerosis and also
during coagulation, but its measurement requires complex and expensive
instrumentation and is thus rarely done. We propose to develop an ultrasonic
technique to simplify this measurement using small samples of blood. An
ultrasound beam produces streaming in fluids, and a pulsed Doppler velocimeter
can be used to both induce and measure the streaming velocity which is
determined by both the acoustic and physical properties of the fluid. In
addition, the time constant to a step change in acoustic power is also a
function of viscosity and density. We propose during Phase I to develop a 20
MHz pulsed Doppler and signal processing to show: 1) that streaming can be
measured in 50 mu1 of canine or murine blood with a 1 mm transducer; 2) that the
streaming velocity and time constant are functions of viscosity; and 3) that
streaming is reproducible and stable. During Phase II we will model the
streaming process using finite difference methods, and based on the results
will design an instrument and apparatus optimized for measuring viscosity in
small samples of freshly drawn whole blood. This technique could also become
the basis of a whole-blood coagulation detector and timer and could be
incorporated into a laboratory analyzer. In research it will be used to study
hemorheology in genetically altered mice.
PROPOSED COMMERCIAL APPLICATION:
The testing of blood is a major activity in hospital laboratories, and the concepts to be
developed here could be incorporated into the measurement of coagulation timing and
viscosity. The measurement of blood viscosity at the bedside for diagnosis and for
monitoring of therapeutic manipulations is essentially a new market where the
implications could be very great.
描述(来自申请人摘要的逐字):血液粘度改变,
疾病如镰状细胞性贫血、高血压和动脉粥样硬化,
但其测量需要复杂且昂贵的
仪器,因此很少使用。我们建议开发一种超声波
使用少量血液样本简化这种测量的技术。一个
超声波束在液体中产生流动,脉冲多普勒速度计
可以用来感应和测量流动速度,
这由流体的声学和物理性质决定。在
此外,声功率阶跃变化的时间常数也是
粘度和密度的函数。我们建议在第一阶段制定一项20
MHz脉冲多普勒和信号处理,以显示:1)流可以
用1 mm传感器在50 μ l犬或鼠血液中测量; 2)
流动速度和时间常数是粘度的函数;以及3)
流式传输是可再现的和稳定的。在第二阶段,我们将模拟
流过程采用有限差分法,并根据计算结果
将设计一种仪器和设备,用于测量粘度,
新鲜抽取的少量全血样本。这项技术也可以成为
全血凝固检测器和计时器的基础,
被纳入实验室分析仪。在研究中,它将用于研究
转基因小鼠的血液流变学
拟定商业应用:
血液检测是医院实验室的一项主要活动,
这里开发的可以被纳入凝血时间的测量,
粘度 床边血液粘度测定在诊断和治疗中的应用
治疗操作的监测基本上是一个新市场,
影响可能非常大。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Craig J. Hartley其他文献
Review of intracoronary Doppler catheters
- DOI:
10.1007/bf01745146 - 发表时间:
1989-06-01 - 期刊:
- 影响因子:1.500
- 作者:
Craig J. Hartley - 通讯作者:
Craig J. Hartley
SEGMENTAL ANALYSIS OF CIRCUMFERENTIAL SYSTOLIC CAROTID ARTERIAL STRAIN IN DIABETICS AND HYPERTENSIVES USING 2D SPECKLE TRACKING
- DOI:
10.1016/s0735-1097(12)61643-x - 发表时间:
2012-03-27 - 期刊:
- 影响因子:
- 作者:
Eric Y. Yang;Gerd Brunner;Hisham Dokainish;Salim Virani;Nasser Lakkis;Arunima Misra;Marti McCulloch;Craig J. Hartley;Joel D. Morrisett;Christie Ballantyne;Sherif Nagueh;Vijay Nambi - 通讯作者:
Vijay Nambi
Effects of severity and eccentricity of carotid stenosis on pulsatile blood flow
颈动脉狭窄的严重程度和偏心率对脉动血流的影响
- DOI:
10.1109/iembs.2002.1106403 - 发表时间:
2002 - 期刊:
- 影响因子:0
- 作者:
Staffan Lundin;W. Metcalfe;Craig J. Hartley - 通讯作者:
Craig J. Hartley
Characteristics of acoustic streaming created and measured by pulsed Doppler ultrasound
脉冲多普勒超声产生和测量的声流特性
- DOI:
10.1109/58.656631 - 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
Craig J. Hartley - 通讯作者:
Craig J. Hartley
Comparison of the cardiovascular action of isoproterenol, dopamine, and dobutamine in the neonatal and mature dog
异丙肾上腺素、多巴胺和多巴酚丁胺对新生犬和成年犬心血管作用的比较
- DOI:
10.1007/bf02336436 - 发表时间:
1980-12-01 - 期刊:
- 影响因子:1.400
- 作者:
David J. Driscoll;Paul C. Gillette;Junichiro Fukushige;Robert M. Lewis;Charles Contant;Craig J. Hartley;Mark L. Entman;Arnold Schwartz;Frank Dunn - 通讯作者:
Frank Dunn
Craig J. Hartley的其他文献
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{{ truncateString('Craig J. Hartley', 18)}}的其他基金
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
6658786 - 财政年份:2002
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
6348245 - 财政年份:2000
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
6206567 - 财政年份:1999
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
6123428 - 财政年份:1998
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
2215577 - 财政年份:1978
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
2685279 - 财政年份:1978
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
3336903 - 财政年份:1978
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
3336904 - 财政年份:1978
- 资助金额:
$ 9.17万 - 项目类别:
ULTRASONIC INSTRUMENTATION FOR CARDIOVASCULAR STUDIES
用于心血管研究的超声波仪器
- 批准号:
3336900 - 财政年份:1978
- 资助金额:
$ 9.17万 - 项目类别: