ULTRASONIC BLOOD VISCOMETER

描述(逐字摘自申请者摘要)：血液粘度在 镰状细胞性贫血、高血压和动脉粥样硬化等疾病，以及 但它的测量需要复杂和昂贵的 仪器，因此很少这样做。我们建议开发一种超声波 使用少量血液样本来简化这一测量的技术。一个 超声束在流体中产生流动，脉冲多普勒测速仪 可以用来感应和测量流动速度，即 由流体的声学和物理性质决定。在……里面 此外，声功率阶跃变化的时间常数也是 粘度和密度的函数。我们建议在第一阶段开发一个20 MHZ脉冲多普勒和信号处理表明：1)流可以 用1 mm换能器测量50 MU1的犬或鼠血；2) 流动速度和时间常数是粘度的函数；以及3) 流媒体是可重现和稳定的。在第二阶段，我们将对 利用有限差分方法进行流水处理，并根据计算结果 将设计一种优化的仪器和仪器来测量粘度 新鲜提取的全血的小样本。这项技术也可能成为 全血凝固检测器和计时器的基础，可以是 结合到实验室分析器中。在研究中，它将被用于研究 转基因小鼠的血液流变学。 建议的商业应用： 血液检测是医院实验室的一项主要活动，其概念将是 本发明可用于混凝时间和时间的测量 粘度。床边血液粘度测定在诊断和治疗中的应用 治疗操作的监测本质上是一个新的市场，在这里 其影响可能非常巨大。

DESCRIPTION (Verbatim from Applicant's Abstract): Blood viscosity is altered in diseases such as sickle cell anemia, hypertension, and atherosclerosis and also during coagulation, but its measurement requires complex and expensive instrumentation and is thus rarely done. We propose to develop an ultrasonic technique to simplify this measurement using small samples of blood. An ultrasound beam produces streaming in fluids, and a pulsed Doppler velocimeter can be used to both induce and measure the streaming velocity which is determined by both the acoustic and physical properties of the fluid. In addition, the time constant to a step change in acoustic power is also a function of viscosity and density. We propose during Phase I to develop a 20 MHz pulsed Doppler and signal processing to show: 1) that streaming can be measured in 50 mu1 of canine or murine blood with a 1 mm transducer; 2) that the streaming velocity and time constant are functions of viscosity; and 3) that streaming is reproducible and stable. During Phase II we will model the streaming process using finite difference methods, and based on the results will design an instrument and apparatus optimized for measuring viscosity in small samples of freshly drawn whole blood. This technique could also become the basis of a whole-blood coagulation detector and timer and could be incorporated into a laboratory analyzer. In research it will be used to study hemorheology in genetically altered mice. PROPOSED COMMERCIAL APPLICATION: The testing of blood is a major activity in hospital laboratories, and the concepts to be developed here could be incorporated into the measurement of coagulation timing and viscosity. The measurement of blood viscosity at the bedside for diagnosis and for monitoring of therapeutic manipulations is essentially a new market where the implications could be very great.