Dubbo Osteoporosis Epidemiology Study

达博骨质疏松症流行病学研究

• 批准号: nhmrc : 276413
• 负责人: Prof Jacqueline Center
• 金额: $ 45.1万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dubbo-osteoporosis-epidemiology-study/96809
• 关键词: Dubbo; Osteoporosis; Epidemiology; Study

Osteoporosis is a major and increasing public health problem. Fracture, the ultimate consequence of osteoporosis is associated with significant morbidity, mortality and economic costs. The Dubbo Osteoporosis Epidemiology Study, starting in 1989, with over 2000 women and men, is one of the longest running epidemiological studies in osteoporosis worldwide. It has been at the forefront of epidemiological advances in osteoporosis. It has identified osteoporotic fracture risks including low bone density and bone loss, muscle weakness and postural instability, as well as the extent of the problem in men, and the significant costs, ill-heath and mortality associated with fracture. Despite the clarification of risk factors over the past decade, there are significant gaps in knowledge about osteoporosis, particularly in the accurate prediction of fracture risk and in identification of factors related to fracture-associated mortality and survival post fracture. Although bone density is one of the best predictors of fracture risk, it incompletely discriminates between those who will fracture from those who will not. Although a number of clinical risk factors, and other measures of bone strength, such as quantitative ultrasound and geometry, have been shown to be independent predictors of fracture risk, it is not clear that these measures can be integrated with BMD to improve fracture prediction. The aim of the current study, is to develop and validate models using bone density, other measures of bone strength and clinical parameters that will more accurately predict fracture risk and mortality following fracture in older men and women. The more precise identification of those at high risk of fracture and at risk for poor outcomes following fracture will provide a rational basis for the development of more cost effective interventions for prevention of fracture and its associated morbidity and mortality.

骨质疏松症是一个日益严重的重大公共卫生问题。骨折是骨质疏松症的最终后果，与显著的发病率、死亡率和经济成本相关。Dubbo骨质疏松流行病学研究始于1989年，涉及2000多名女性和男性，是世界上持续时间最长的骨质疏松症流行病学研究之一。它一直处于骨质疏松症流行病学进展的前沿。它已经确定了骨质疏松性骨折的风险，包括低骨密度和骨质流失，肌肉无力和姿势不稳定，以及男性问题的程度，以及与骨折相关的重大成本，不健康和死亡率。尽管过去十年对骨质疏松症的危险因素有了明确的认识，但对骨质疏松症的认识仍有很大的差距，特别是在准确预测骨折风险以及确定与骨折相关的死亡率和骨折后生存相关的因素方面。虽然骨密度是骨折风险的最佳预测指标之一，但它不能完全区分哪些人会骨折，哪些人不会。尽管许多临床危险因素和其他骨强度测量，如定量超声和几何形状，已被证明是骨折风险的独立预测因素，但尚不清楚这些测量是否可以与BMD相结合以改善骨折预测。当前研究的目的是开发和验证使用骨密度、其他骨强度测量和临床参数的模型，这些模型将更准确地预测老年男性和女性骨折后的骨折风险和死亡率。更精确地识别骨折高风险和骨折后不良预后风险，将为开发更具成本效益的干预措施提供合理基础，以预防骨折及其相关的发病率和死亡率。