EPIDEMIOLOGY OF OSTEOPOROSIS IN WOMEN WITH LUPUS - MAMDC PROJECT

狼疮女性骨质疏松症的流行病学 - MAMDC 项目

基本信息

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The specific aims to be addressed in this study are: 1) To estimate the differences in bone mineral density (BMD) at the hip and lumbar spine between 240 women with lupus and a comparable control group of 200 women matched by age, race, and menopause status; 2) To determine the association of lupus risk factors with low BMD in women with lupus, after controlling for traditional risk factors for low BMD; 3) To follow the subjects entered in the cross-sectional study over a two year period in order to estimate the difference in the rate of bone loss at the hip and lumbar spine between women with lupus and a comparable control group matched by age, race, and menopause status; and 4) To determine the association of lupus risk factors with increased rates of bone loss in women with lupus, after controlling for traditional risk factors for low BMD. The hypotheses to be examined in this study are: 1a) women with lupus have lower BMD at the hip and spine than matched controls; 1b) the negative effect of lupus on bone mineral density at the hip and spine is greater in Caucasian than in African-American women; 2a) traditional risk factors for low BMD (multiparty and menopause status, irregular menstrual cycles or premature menopause, avoidance of oral contraceptives and/or hormone replacement therapy, lower physical activity level, and decreased vitamin D levels) are associated with lower BMD at the hip or lumbar spine in women with lupus; 2b) lupus risk factors (greater disease activity, greater disease severity, higher corticosteroid burden, use of anticonvulsant drugs, and the presence of renal disease) are associated with lower BMD at the hip or lumbar spine in women with lupus, after controlling for traditional risk factors for low BMD; 3a) women with lupus have accelerated bone loss at the hip and spine during two additional years of lupus disease compared with matched controls followed for two years; 3b) the effect of lupus on the rate of bone loss at the hip and spine is greater in Caucasian than in African-American women; 4a) traditional osteoporosis risk factors (mentioned in 2a above) are associated with accelerated bone loss in women with lupus; and 4b) lupus risk factors (mentioned in 2b above) are associated with accelerated bone loss at the hip or lumbar spine in women with lupus, after controlling for traditional risk factors for low BMD.
这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 本研究的具体目的是:1)估计240名狼疮妇女和200名年龄、种族和绝经状态相匹配的对照组妇女的髋部和腰椎骨矿物质密度(BMD)的差异; 2)在控制了传统的低BMD危险因素后,确定狼疮危险因素与女性狼疮患者低BMD的相关性; 3)对进入横断面研究的受试者进行为期两年的随访,以估计狼疮女性与年龄、种族和绝经状态相匹配的可比对照组之间髋关节和腰椎骨丢失率的差异;和4)为了确定狼疮危险因素与狼疮妇女骨丢失率增加的相关性,在控制了低BMD的传统危险因素后。 本研究中要检验的假设是:1a)患有狼疮的女性髋部和脊柱的骨密度低于匹配的对照组; 1b)狼疮对白人髋部和脊柱骨矿物质密度的负面影响大于非裔美国女性; 2a)低BMD的传统风险因素(多配偶和绝经状态,月经周期不规则或过早绝经,避免口服避孕药和/或激素替代疗法,体力活动水平较低,和维生素D水平降低)与狼疮女性髋部或腰椎BMD降低有关; 2b)狼疮危险因素(更大的疾病活动性,更严重的疾病,更高的皮质类固醇负荷,抗惊厥药物的使用,以及肾脏疾病的存在)与狼疮女性的髋关节或腰椎BMD降低相关,在控制了低BMD的传统危险因素后; 3a)与匹配的对照组相比,狼疮妇女在狼疮疾病的另外两年中在髋部和脊柱处加速了骨质流失; 3b)狼疮对髋部和脊柱处骨质流失率的影响在白人中比在非洲裔美国妇女中更大; 4a)传统的骨质疏松症风险因素(在上面2a中提到)与患有狼疮的女性中的加速的骨丢失相关;以及4 b)在控制了低BMD的传统风险因素之后,狼疮风险因素(在上面2b中提到)与患有狼疮的女性中的髋部或腰椎处的加速的骨丢失相关。

项目成果

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Rosalind Ramsey-Goldman其他文献

Rosalind Ramsey-Goldman的其他文献

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{{ truncateString('Rosalind Ramsey-Goldman', 18)}}的其他基金

Differentiating clinical characteristics between two subtypes of antiphosphatidylethanolamine
区分抗磷脂酰乙醇胺两种亚型的临床特征
  • 批准号:
    10654055
  • 财政年份:
    2022
  • 资助金额:
    $ 0.32万
  • 项目类别:
Differentiating clinical characteristics between two subtypes of antiphosphatidylethanolamine
区分抗磷脂酰乙醇胺两种亚型的临床特征
  • 批准号:
    10510394
  • 财政年份:
    2022
  • 资助金额:
    $ 0.32万
  • 项目类别:
Cancer risk after renal transplant in autoimmune disease
自身免疫性疾病肾移植后的癌症风险
  • 批准号:
    8387402
  • 财政年份:
    2012
  • 资助金额:
    $ 0.32万
  • 项目类别:
Cancer risk after renal transplant in autoimmune disease
自身免疫性疾病肾移植后的癌症风险
  • 批准号:
    8507183
  • 财政年份:
    2012
  • 资助金额:
    $ 0.32万
  • 项目类别:
Fatigue and Lifestyle Physical Activity in SLE
SLE 患者的疲劳和生活方式体力活动
  • 批准号:
    8114607
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
Fatigue and Lifestyle Physical Activity in SLE
SLE 患者的疲劳和生活方式体力活动
  • 批准号:
    8318574
  • 财政年份:
    2011
  • 资助金额:
    $ 0.32万
  • 项目类别:
Study of Lupus Vascular and Bone Longterm Endpoints
狼疮血管和骨骼长期终点研究
  • 批准号:
    7665020
  • 财政年份:
    2008
  • 资助金额:
    $ 0.32万
  • 项目类别:
Study of Lupus Vascular and Bone Longterm Endpoints
狼疮血管和骨骼长期终点研究
  • 批准号:
    7267276
  • 财政年份:
    2007
  • 资助金额:
    $ 0.32万
  • 项目类别:
PREDICTORS OF PREGNANCY OUTCOMES IN SLE AND APS
SLE 和 APS 妊娠结局的预测因素
  • 批准号:
    7604310
  • 财政年份:
    2006
  • 资助金额:
    $ 0.32万
  • 项目类别:
TRANSESOPHAGEAL ECHOCARDIOGRAPHY EVALUATION AND MRI OF THE AORTA IN LUPUS
狼疮主动脉的经食管超声心动图评估和 MRI
  • 批准号:
    7604326
  • 财政年份:
    2006
  • 资助金额:
    $ 0.32万
  • 项目类别:

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Epidemiology of knee osteoarthritis, lumbar spondylosis and osteoporosis in Japanese men and women : The Research on Osteoarthritis/osteoporosis Against Disability(ROAD)
日本男性和女性膝骨关节炎、腰椎病和骨质疏松症的流行病学:骨关节炎/骨质疏松症抗残疾研究(ROAD)
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Epidemiology of Genetic Risk Factors for Osteoporosis in Older Men and Women
老年男性和女性骨质疏松症遗传危险因素的流行病学
  • 批准号:
    7532225
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Epidemiology of Genetic Risk Factors for Osteoporosis in Older Men and Women
老年男性和女性骨质疏松症遗传危险因素的流行病学
  • 批准号:
    7673539
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Epidemiology of Genetic Risk Factors for Osteoporosis in Older Men and Women
老年男性和女性骨质疏松症遗传危险因素的流行病学
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EPIDEMIOLOGY OF OSTEOPOROSIS IN WOMEN WITH LUPUS - MAMDC PROJECT
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  • 批准号:
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  • 财政年份:
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EPIDEMIOLOGY OF OSTEOPOROSIS IN WOMEN WITH LUPUS - MAMDC PROJECT
狼疮女性骨质疏松症的流行病学 - MAMDC 项目
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Epidemiology of Osteoporosis in Women with Lupus - MAMDC Project
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