NATURAL HISTORY OF PROSTATISM--THE OLMSTED COUNTY STUDY

前列腺疾病的自然史——奥姆斯特德县研究

• 批准号: 6381946
• 负责人: STEVEN J JACOBSEN
• 金额: $ 65.76万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6381946
• 关键词: aging; benign prostate hyperplasia; clinical research; data collection methodology /evaluation; disease /disorder etiology; fluid flow; human population study; human subject; longitudinal human study; male; medical complication; outcomes research; pathologic process; prostate specific antigen; questionnaires; statistics /biometry; ultrasonography; urinalysis; urine

The Olmsted County Study of Urinary Symptoms and Health Status among Men is a prospective cohort study of urologic aging in a random sample of over 2,000 community-dwelling men. This study has made a number of significant contributions to our understanding of the natural history of signs and symptoms related to benign prostatic hyperplasia (BPH) that are free from the biases present in clinical series of patients. These findings, however, are limited to an initial ten years of follow-up that was funded by Merck Research Labs. Since BPH is a chronic, progressive disease and complications are manifest over extended periods, the continued follow-up of this cohort is necessary to accrue sufficient events to provide long-term risk information. These data are not presently available but are necessary to make informed clinical decisions. Furthermore, extending follow-up will increase the precision of estimates of change in surrogate measures of BPH, providing better insight into what would be expected in community-dwelling men in the absence of a clinical trial setting. The continued follow-up also will provide a better understanding of how serum PSA levels change over time. The specific aims for this application are designed to expand upon our previous findings with an additional four years of follow-up using our well-established protocols. We will determine the 14-year progression of clinical (symptoms), physiologic (peak urinary flow rates) and anatomic (prostate volume) surrogate measures of BPH (Aim 1). We will examine how these vary together over time (Aim 2) and gather information on long-term risk of complications and treatment and relate this to the surrogate measures of BPH (Aim 3). We will also assess the longitudinal changes in serum PSA levels (Aim 4) in order to increase our understanding of the relationship between increases in PSA levels and prostate growth in the absence of cancer. Thus, with the completion of these aims, we will have provided much-needed insight into the role of surrogate measures of BPH in understanding the natural history of this condition in the community at large. This information will prove useful in the design of future clinical trials and epidemiologic studies. Furthermore, we will have provided information that is necessary for informed clinical decision making for treatment of BPH.

奥姆斯特德县泌尿系统症状和健康状况研究 男性中的一项随机样本的泌尿系统衰老前瞻性队列研究 超过 2,000 名社区居民。这项研究取得了多项重大成果 对我们理解体征和症状的自然史的贡献 与良性前列腺增生（BPH）相关，不受偏见影响 存在于临床系列患者中。然而，这些发现仅限于 由默克研究实验室资助的最初十年的后续研究。自从 BPH 是一种慢性、进行性疾病，并发症在 较长时期内，有必要对该队列进行持续随访，以积累 足够的事件来提供长期风险信息。这些数据不是 目前可用，但对于做出明智的临床决策是必要的。 此外，延长后续行动将提高估计的精确度 BPH 替代指标的变化，提供了更好的洞察力 在没有临床试验的情况下，预计社区居住的男性会出现这种情况 环境。持续的跟进也将让我们更好地了解 血清 PSA 水平如何随时间变化。此应用程序的具体目标 旨在以额外四年的时间扩展我们之前的发现 使用我们完善的协议进行后续行动。我们将确定 临床（症状）、生理（峰值尿流量）的 14 年进展 率）和 BPH 的解剖学（前列腺体积）替代指标（目标 1）。我们 将检查这些随着时间的推移如何变化（目标 2）并收集信息 并发症和治疗的长期风险，并将其与 BPH 的替代指标（目标 3）。我们还将评估纵向变化 血清 PSA 水平（目标 4），以增加我们对 PSA水平升高与前列腺生长之间的关系 癌症。因此，随着这些目标的完成，我们将提供 急需深入了解 BPH 替代指标在理解中的作用 整个社区中这种情况的自然历史。这 信息将被证明对未来临床试验的设计有用 流行病学研究。此外，我们将提供以下信息： 对于 BPH 治疗的明智临床决策是必要的。