权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Experimental and mathematical modelling to evaluate and optimize the effectiveness of the predatory bacterium Bdellovibrio bacteriovorus as an alterna

用于评估和优化捕食性细菌噬菌蛭弧菌作为替代细菌的有效性的实验和数学模型

基本信息

批准号：
1644294
负责人：
金额：
--
依托单位：
University of Birmingham
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1644294
关键词：
Experimental mathematical modelling evaluate optimize

项目摘要

The bacterium Bdellovibrio is a predator that kills other bacteria including plant, animal and human pathogens and has been proposed as an alternative to antibiotics. In order to use Bdellovibrio, we need to know how much it can reduce the population of prey and whether it would prefer certain prey when offered a choice from many potential prey. Does the presence of many prey species lead to better or worse performance of the predator, and how much of a problem is the presence of non-prey species? We will investigate these questions by a combination of experimental studies and mathematical modelling. Both will start with simple systems of only one prey species and move to systems with several prey species. This will allow us to understand the effect of increasing biodiversity on predator performance. Moreover, we will compare spatially mixed systems with spatially structured systems such as biofilms as pathogens forming biofilms are particularly difficult to treat. Biofilms are densely packed clusters of bacterial cells immobilized in a self-produced slimy substance. This will reveal whether the predator can more easily sense the presence of biofilms compared to single bacteria swimming around. The higher local density of bacteria in biofilms may allow the predator to survive at lower total prey numbers as potential prey are grouped together in one target. The work will contribute to assess the potential of predators to replace or complement the use of antibiotics.

蛭弧菌是一种捕食者，可以杀死其他细菌，包括植物，动物和人类病原体，并已被提议作为抗生素的替代品。为了使用蛭弧菌，我们需要知道它能在多大程度上减少猎物的数量，以及当从许多潜在的猎物中选择时，它是否会更喜欢某些猎物。许多猎物的存在是否会导致捕食者的表现更好或更差，以及非猎物物种的存在有多大的问题？我们将通过实验研究和数学建模相结合来研究这些问题。两者都将从只有一个猎物物种的简单系统开始，然后转移到有几个猎物物种的系统。这将使我们能够了解增加生物多样性对捕食者表现的影响。此外，我们将比较空间混合系统与空间结构系统，如生物膜，因为形成生物膜的病原体特别难以处理。生物膜是固定在自产的粘糊糊的物质中的密集的细菌细胞簇。这将揭示捕食者是否能更容易地感觉到生物膜的存在相比，单一的细菌游泳。生物膜中较高的细菌局部密度可能使捕食者在较低的总猎物数量下生存，因为潜在的猎物集中在一个目标中。这项工作将有助于评估捕食者取代或补充抗生素使用的潜力。