Dynamic trafficking of amino acid transporters at synapses and their role in regulating neurotransmission

突触氨基酸转运蛋白的动态运输及其在调节神经传递中的作用

• 批准号: nhmrc : GNT1105857
• 负责人: A/Pr Brian Billups
• 金额: $ 42.12万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dynamic-trafficking-amino-regulating-neurotransmission/1346470
• 关键词: Dynamic; trafficking; amino; acid; transporters

Brain cells release chemical neurotransmitters to activate their neighbours. The most abundant neurotransmitter is glutamate, which mediates most of the communication in the brain. Following release, this neurotransmitter must be rapidly recycled to prevent levels being depleted and neurotransmission failing. The subject of this grant is to understand what molecules and pathways are used to recycle glutamate in the brain, and how its supply is controlled to sustain continual brain activation.

脑细胞释放化学神经递质来激活它们的邻居。最丰富的神经递质是谷氨酸，它介导大脑中的大部分通讯。释放后，这种神经递质必须迅速回收，以防止水平耗尽和神经传递失败。这笔赠款的主题是了解哪些分子和途径用于回收大脑中的谷氨酸，以及如何控制其供应以维持持续的大脑激活。