ATHEROSCLEROSIS AND RISK OF AGE-RELATED MACULOPATHY

描述：（申请人摘要）本流行病学研究的目的是 评估全身性动脉粥样硬化的标志物与 老年性黄斑病变早、晚期发病率 基于人群的巢式事件病例对照研究。该提案基于 比弗坝人口老龄化研究：比弗坝之眼 研究（EY06594）和听力损失流行病学研究（AG11099）。 发生早期年龄相关性黄斑病变或发生晚期黄斑病变的受试者 根据标准化照片分级确定的年龄相关性黄斑病变 在相隔五年的两次考试中参加考试的人， study.参与者在10年的时间没有年龄相关的黄斑病变 后续眼部检查将作为对照。早期病例 将按年龄和性别与对照组进行频率匹配， 对照组与病例组的比例。发生的晚期年龄相关性黄斑病变病例将 按年龄和性别与对照组频率匹配，使用三比一的比例， 控制案件。基于预期的5年发病率和参与率 在这两项研究中，我们估计共有189例事件 378例对照组和34例迟发性老年性黄斑病变 年龄相关性黄斑病变和102名对照将被纳入本研究。 全身性动脉粥样硬化将通过内膜-中层厚度和 颈动脉中存在斑块。存储的B模式录像带 在流行病学调查中， 听力损失研究，使用动脉粥样硬化风险的修改， 社区研究方案。这些扫描将被读取，并测量 使用社区动脉粥样硬化风险测量内膜-中层厚度 超声阅读方案。 视网膜相关性黄斑病变是公认的主要致盲原因 在老年人中，这是老年人的一个重大公共卫生问题。作为 然而，没有办法预防或有效治疗这种疾病。本研究 将提供重要的流行病学信息， 动脉粥样硬化在老年性黄斑病变病因学中的作用。它利用 一个独特的机会来评估这种联系，利用现有的 基于人群的队列研究，标准化评估 年龄相关性黄斑病变和标准化颈动脉超声扫描。

DESCRIPTION: (Applicant's Abstract) The purpose of this epidemiologic study is to evaluate the association of markers of generalized atherosclerosis with the incidence of early and late stage age-related maculopathy in a population-based, nested incident case-control study. This proposal builds on the population-based studies of aging in Beaver Dam, WI: The Beaver Dam Eye Study (EY06594) and the Epidemiology of Hearing Loss Study (AG11099). Participants with incident early age-related maculopathy or incident late-stage age-related maculopathy as determined from grading of standardized photographs taken at two examinations five years apart will be eligible as cases for this study. Participants without age-related maculopathy at the time of the 1 0-yr follow-up eye examination will be eligible as controls. Incident early cases will be frequency-matched by age and gender to controls using a two-to-one ratio of controls to cases. Incident late age-related maculopathy cases will be frequency-matched to controls by age and gender using a three-to-one ratio of controls to cases. Based on expected 5-yr incidence rates and participation rates in both studies, we estimate that a total of 189 cases with incident early age-related maculopathy and 378 controls and 34 cases with incident late age-related maculopathy and 102 controls will be included in this study. Generalized atherosclerosis will be measured by intima-medial thickness and the presence of plaque in the carotid arteries. Stored videotapes of B mode ultrasound scans of the carotid arteries were obtained as of the Epidemiology of Hearing Loss Study, using a modification of the Atherosclerosis Risk in Communities Study protocol. These scans will be read, and measurements of the intima-medial thickness made, using the Atherosclerosis Risk in Communities ultrasound reading protocol. Age-related maculopathy is well-recognized to be the leading cause of blindness among older adults and a significant public health problem for older adults. As yet there is no way to prevent or effectively treat this disorder. This study will provide important epidemiologic information about the role of atherosclerosis in the etiology of age-related maculopathy. It takes advantage of an unique opportunity to evaluate this association by utilizing an existing population-based cohort with standardized assessments of the incidence of age-related maculopathy and standardized carotid artery ultrasound scans.