New technologies for targeted delivery of anti-bacterial agents

抗菌药物靶向递送新技术

• 批准号: 1654774
• 金额: --
• 依托单位: University of East Anglia
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1654774
• 关键词: New; technologies; targeted; delivery; anti

In a climate of prevailing antibiotic resistant bacteria, there is a pressing need for new ways to control infectious disease. This project aims to create a novel carbohydrate-based technology for selectively targeting anti-bacterial agents to specific bacterial species, in order to enable the selective eradication of pathogens in mixed microbial populations. Depending on the skills and interests of the student, the project will involve a combination of chemistry, biochemistry, nanoparticle generation and modification, and in vitro microbiology studies. There will also be scope to explore model gut and model organism analyses of potential clinical and commercial relevance. This multidisciplinary project brings together complementary academic and industrial expertise from the John Innes Centre and Procarta Biosystems Ltd.

在抗生素耐药性细菌盛行的环境中，迫切需要新的方法来控制传染病。该项目旨在创造一种新的基于碳水化合物的技术，以选择性地针对特定细菌物种的抗菌剂，以便能够选择性地根除混合微生物种群中的病原体。根据学生的技能和兴趣，该项目将涉及化学、生物化学、纳米颗粒的产生和修饰以及体外微生物学研究。还将有机会探索潜在的临床和商业相关性的模型肠道和模型生物体分析。这个多学科项目汇集了约翰·因斯中心和普罗卡塔生物系统有限公司互补的学术和工业专业知识。