Phosphorus Bioisosteres of the Sulfonyl Group: New Chemical Space

磺酰基的磷生物等排体：新的化学空间

• 批准号: 1666851
• 金额: --
• 依托单位: University of Nottingham
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1666851
• 关键词: Phosphorus; Bioisosteres; Sulfonyl; Group; New

The sulfonyl group, -SO2-, is frequently represented in both agrochemical and pharmaceutical active ingredients. This collaborative proposal will deliver organophosphorus-based bioisosteric mimics of this important functional group giving access to new chemical space and IP opportunities. This will be achieved through the development of new synthesis methods for phosphines, phosphonates and phosphinates that by-pass toxic PCl3 and other difficult-to-handle halophosphine intermediates. The project falls within the EPSRC's remit, specifically involving research in the areas of Synthetic Organic Chemistry and Chemical Biology and Biological Chemistry.

磺酰基-SO2-经常出现在农用化学品和药物活性成分中。这项合作提案将提供这一重要官能团的基于有机磷的生物电子等排模拟物，从而获得新的化学空间和IP机会。这将通过开发新的膦、膦酸酯和次膦酸酯合成方法来实现，这些方法可以绕过有毒的PCl 3和其他难以处理的卤代膦中间体。该项目福尔斯EPSRC的职权范围，特别是涉及合成有机化学和化学生物学和生物化学领域的研究。