ADVANCED HIGH SPEED HIGH RESOLUTION POSITRON TOMOGRAPH

先进的高速高分辨率正电子断层扫描仪

• 批准号: 6457043
• 负责人: STEPHEN E. DERENZO
• 金额: $ 9.05万
• 依托单位: UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6457043
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; cardiography; clinical biomedical equipment; computer program /software; diagnosis design /evaluation; heart circulation; heart disorder diagnosis; heart imaging /visualization /scanning; heart metabolism; noninvasive diagnosis; phantom model; photomultiplier; positron emission tomography; radiation detector

The overall objective of this project is to provide an advanced animal whole body/human brain positron tomograph for the medical science projects. This tomograph will make possible quantitative measurements of cardiovascular physiology in animal models by permitting high count rate dynamic studies with bolus injections of flow and metabolic tracers. It has the following advanced features: Lutetium orthosilicate (LSO) scintillators, which have 6 times greater light output and 8 times faster decay time than bismuth germanate (BGO). Photomultiplier tube readout to provide pulse height information (to reject scattered annihilation photons) and a timing resolution less than 1 ns (to reject random backgrounds). Small (1.5 - 2.5 mm) crystals, read out individually by low-noise silicon photodiodes. Depth of interaction measurement for less than 2 mm spatial resolution over the imaging volume. Small detector dimaeter of 35 cm for low noncollinearity error, high sensitivity, and reduced cost. Full 3D mode over a subject port of 30 cm and an axial field of 15 cm (no inter-plane septa), for high sensitivity and a maximum noise equivalent event rate of greater than 700 k/s at 1 muCi/m1. We expect that U.S. Department of Energy funding will support purchase of the components needed for the 270 detector modules, that CTI PET Systems will provide the labor to assemble and test them, and that this project will provide the following: Construction, testing, and evaluation of pre-production detection modules. Assembling 270 pre-tested detector modules in a gantry at LBL. Evaluating the completed high resolution tomograph. Developing attenuation measurement, background correction, and calibration procedures. This project will advance the technology further by developing time-of-flight capability and installing it in the high resolution LSO tomograph. Our goal is a timing resolution less than 500 ps, which corresponds to less than 7.5 cm. This improves the signal-to-noise ration in the reconstructed 3D images by further reducing the random coincidence background and by localizing the events in 3D to reduce error propagation in the reconstruction process.

该项目的总体目标是提供一个先进的 用于医学的动物全身/人脑正电子断层扫描 科学项目。这一断层摄影术将使定量成为可能 在动物模型中测量心血管生理学 允许通过团注进行高计数率动态研究 流动和代谢示踪剂。它具有以下高级功能： 锶正硅酸盐(LSO)闪烁体，具有6倍 更大的光输出和比铋快8倍的衰减时间 锗(BGO)。光电倍增管读数提供脉冲 高度信息(以拒绝散射湮没光子)和 定时分辨率低于1 ns(以抑制随机背景)。 小(1.5-2.5毫米)晶体，由低噪声单独读出 硅光电二极管。小于的相互作用深度测量 成像体积上的空间分辨率为2 mm。小型探测器 直径35厘米，低非共线误差，高灵敏度， 并降低了成本。全3D模式覆盖30厘米的对象端口和 15厘米的轴向磁场(无平面间隔膜)，用于高灵敏度 最大噪声当量事故率大于700k/S 在1 Muci/M1处。我们预计美国能源部的资金 将支持购买270所需的组件 探测器模块，CTI PET系统将提供劳动力 组装和测试它们，并且这个项目将提供 以下内容：试生产的建设、测试和评估 检测模块。组装270个预先测试的探测器模块 LBL的一个龙门架。评估已完成的高分辨率 体层摄影术。展开衰减测量，背景 校正和校准程序。这项工程将会取得进展 该技术通过开发飞行时间能力和 安装在高分辨率的LSO断层摄影仪上。我们的目标是 定时分辨率小于500 ps，对应于小于 7.5厘米。这提高了信噪比在 通过进一步降低随机性来重建3D图像 重合背景，并通过在3D中定位事件来 减少重建过程中的错误传播。