HIGH RESOLUTION PET DETECTOR USING SOLID-STATE PHOTONICS

该项目的总体目标是开发一种新的阻塞检测器 用于多层、高分辨率正电子发射断层扫描的模块 在整个成像领域提供高分辨率、高最大 计数速度快，灵敏度高。相对于现有区块的优势 探测器的设计是较小的块大小，从而产生较高的最大值 闪烁体晶体的重合事件率和个别耦合 定位灵敏的光电二极管，提高了空间分辨率。 这种方法的特点是： 2 mm窄重原子闪烁晶体的单独读数 空间分辨率、最高效率和高最大事件发生率。 用于识别晶体的位置灵敏固态光电探测器 交互和测量交互深度，从而减少 导致径向模糊的位置误差。 这种探测器设计是为定量测量而开发的 具有高空间和时间分辨率的示踪化合物进行测量 特定的血流和新陈代谢。这个项目只建议做证明 以测试台图像为最终结果的原理研究--未完成 将建造断层扫描仪。设计完成后，将是 提供给私营行业的潜在合作者(CTI，Inc. 田纳西州诺克斯维尔已经对这种设计表现出兴趣)谁可能 将其整合到完整的扫描仪中。我们认为探测器模块 Proposed可用于构造以下任一特定的 断层摄影术： 2 mm分辨率2尼姆晶体人脑成像断层扫描仪 覆盖整个大脑。这一断层摄影术将允许对大脑皮质的研究 和脑干生物化学具有足够的分辨率来提供准确的 以4x4x5mm3体积进行量化。 动物断层摄影仪，晶体直径1毫米，分辨率1-1.5毫米。这 系统将能够以前所未有的分辨率拍摄小动物的图像 并接近体内放射自显影的目标，其中动物 用作他们自己的控制。

The overall objective of this project is to develop a new block detector module for multi-layer, high resolution positron emission tomography that provides high resolution over the entire imaging field, high maximum counting rates, and high sensitivity. The advantages over existing block detector designs is a smaller block size, which results in higher maximum coincident event rates, and individual coupling of scintillator crystals to position sensitive photodiodes, which improves the spatial resolution. Special features of this approach are: Individual readout of narrow, heavy-atom scintillation crystals for 2 mm spatial resolution, maximum efficiency, and high maximum event rates. Position-sensitive solid-state photodetectors for identifying the crystal of interaction and measuring depth of interaction, thus reducing the position error that causes radial blurring. This detector design is being developed for the quantitative measurement of tracer compounds with high spatial and temporal resolution to measure specific perfusion and metabolism. This project proposes only to do proof of principle studies culminating with test table images - no complete tomographs will be constructed. The design, when completed, will be offered to potential collaborators in private industry (CTI, Inc. of Knoxville, TN has already shown interest in this design) who may incorporate it into complete scanners. We believe that the detector module proposed can be used to construct either of the following specific tomographs: A human brain imaging tomograph with 2 nun crystals and 2 mm resolution over the entire brain. This tomograph would permit the study of cortical and brain stem biochemistry with sufficient resolution to provide accurate quantitation in 4 x 4 x 5 mm3 volumes. An animal tomograph with 1 mm crystals and 1-1.5 mm resolution. This system would be able to image small animals with unprecedented resolution and approach the goal of in-vivo autoradiography, in which the animals are used as their own controls.