HIGH RESOLUTION PET DETECTOR USING SOLID-STATE PHOTONICS

本项目的总体目标是开发一种新的块检测器 用于多层高分辨率正电子发射断层摄影的模块， 在整个成像区域提供高分辨率， 计数率高，灵敏度高。 与现有街区相比的优势 检测器设计是一个较小的块大小，这导致更高的最大 符合事件率和闪烁体晶体的单独耦合 以定位敏感的光电二极管，这提高了空间分辨率。 这种方法的特点是： 2 mm窄重原子闪烁晶体的单个读数 空间分辨率、最大效率和最高事件率。 用于识别晶体的位置敏感固态光电探测器 的互动和测量互动的深度，从而减少 导致径向模糊的位置误差。 该检测器设计正在开发用于定量测量 具有高空间和时间分辨率的示踪剂化合物， 特异性灌注和代谢。 这个项目建议只做证明 的原则研究最终与测试表图像-不完整 将构建断层扫描仪。 设计完成后，将 提供给私营企业的潜在合作者（CTI，Inc.的 诺克斯维尔，TN已经对此设计表现出兴趣）， 将其整合到完整的扫描仪中。 我们相信探测器模块 建议可用于构建以下特定 断层扫描： 2 mm分辨率2 mm晶体人脑断层显像机 覆盖整个大脑 这种断层扫描可以研究大脑皮层 和脑干生物化学，具有足够的分辨率， 在4 x 4 x 5 mm 3体积中定量。 具有1 mm晶体和1-1.5 mm分辨率的动物断层摄影机。 这 系统将能够以前所未有的分辨率拍摄小动物 并接近体内放射自显影的目标，其中动物被 用作自己的对照。

The overall objective of this project is to develop a new block detector module for multi-layer, high resolution positron emission tomography that provides high resolution over the entire imaging field, high maximum counting rates, and high sensitivity. The advantages over existing block detector designs is a smaller block size, which results in higher maximum coincident event rates, and individual coupling of scintillator crystals to position sensitive photodiodes, which improves the spatial resolution. Special features of this approach are: Individual readout of narrow, heavy-atom scintillation crystals for 2 mm spatial resolution, maximum efficiency, and high maximum event rates. Position-sensitive solid-state photodetectors for identifying the crystal of interaction and measuring depth of interaction, thus reducing the position error that causes radial blurring. This detector design is being developed for the quantitative measurement of tracer compounds with high spatial and temporal resolution to measure specific perfusion and metabolism. This project proposes only to do proof of principle studies culminating with test table images - no complete tomographs will be constructed. The design, when completed, will be offered to potential collaborators in private industry (CTI, Inc. of Knoxville, TN has already shown interest in this design) who may incorporate it into complete scanners. We believe that the detector module proposed can be used to construct either of the following specific tomographs: A human brain imaging tomograph with 2 nun crystals and 2 mm resolution over the entire brain. This tomograph would permit the study of cortical and brain stem biochemistry with sufficient resolution to provide accurate quantitation in 4 x 4 x 5 mm3 volumes. An animal tomograph with 1 mm crystals and 1-1.5 mm resolution. This system would be able to image small animals with unprecedented resolution and approach the goal of in-vivo autoradiography, in which the animals are used as their own controls.