Optical SmartProbe development for Molecular Imaging of the Ex Vivo Perfused Human Lung

用于离体灌注人肺分子成像的光学 SmartProbe 开发

• 批准号: 1732641
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1732641
• 关键词: Optical; SmartProbe; development; Molecular; Imaging

The prospect of an optical biopsy to interrogate the human lungs offers to improve the robustness of clinical trials, drug discovery programmes, while also outcomes for critically ill patients. Optical molecular imaging using smart fluorescent probes offers a safe and affordable technique that will allow analysis of multiple lung pathologies and diseases. Given the lack of current viable chemical probes for the diagnostics of chronic conditions affecting the lungs, the aim of this project is to synthesise several SmartProbes and validate their biological utility. With these probes we will investigate the function of alternatively activated macrophages and the epithelium.

光学活组织检查人类肺部的前景提供了改善临床试验、药物发现计划的稳健性的前景，同时也为危重患者提供了结果。使用智能荧光探针的光学分子成像提供了一种安全和负担得起的技术，将允许分析多种肺部病理和疾病。鉴于目前缺乏可行的化学探针来诊断影响肺部的慢性疾病，该项目的目标是合成几种SmartProbe，并验证它们的生物效用。利用这些探针，我们将研究交替激活的巨噬细胞和上皮细胞的功能。