A SmartPROBE for NMR studies

我们迫切需要一个新的探头为我们的500兆赫核磁共振光谱仪。目前的探针在某些情况下（15 N）损坏无法修复，在其他情况下（溶剂抑制）工作非常差，并且没有观察核氟的能力。500 MHz光谱仪是达尔豪西NMR 3设施中的主力溶液状态仪器，为海洋时代的大量研究人员提供广泛的兴趣。新的探测器将能够在分子水平上研究化学和生物系统，其能力目前在海洋时代无法实现。获得新的探针将使我们能够通过提高我们获得高质量研究数据的能力来显着扩大我们的研究能力，并将为高素质人才的培训提供新的NMR技术和实验。安装Bruker SmartPROBE不会影响光谱仪的功能。SmartPROBE将提供给所有在达尔豪西NMR 3设施使用500 MHz光谱仪的研究人员，而不仅仅是本提案中列出的申请人。

We have an urgent need for a new probe for our 500 MHz NMR spectrometer. The current probe is broken beyond repair in some instances (15N), works very poorly in others (solvent suppression) and has no capability to observe the nucleus fluorine. The 500 MHz spectrometer is the workhorse solution-state instrument in the Dalhousie NMR3 facility and serves a large number of researchers in the Maritimes with a broad spectrum of interests. The new probe will enable the study of chemical and biological systems at a molecular level with capabilities not currently achievable within the Maritimes. Acquisition of the new probe will permit us to significantly expand our research capacity by enhancing our ability to obtain high quality research data for publication, and will provide access to new NMR techniques and experiments for the training of highly qualified personnel. There will be no loss of functionality on the spectrometer by installing a Bruker SmartPROBE whatsoever. The SmartPROBE will be available for all researchers using the 500 MHz spectrometer at the Dalhousie NMR3 facility, not just the applicants listed on this proposal.