Linking genotypic variation of Salmonella Typhimurium

沙门氏菌病是一种食源性传染病，对人类以及野生和家养动物的健康产生重大影响。细菌不断受到被称为噬菌体（phage）的细菌病毒的攻击，这种相互作用对进化产生影响，但也可用于诊断和治疗。本项目将研究鼠伤寒沙门菌噬菌体耐药机制的变化，这将有助于了解一种重要食源性病原体的生物学特性，并有助于发展监测诊断和噬菌体治疗。了解噬菌体排斥的机制与以下方面相关：1)确定监测中噬菌体分型的分子基础；2)了解病原体如何进化；3)提供与噬菌体治疗相关的基础知识。

Salmonellosis is a foodborne infectious disease which has a significant impact on the health of humans, and both wild and domesticated animals. Bacteria are constantly under attack from bacterial viruses called bacteriophage (phage), an interaction with consequences on evolution but that is also exploitable for diagnostics and therapy. This project will investigate the variation in phage resistance mechanisms of Salmonella Typhimurium that will contribute to the understanding of the biology of an important food borne pathogen and to development of surveillance diagnostics and phage therapy. An understanding of the mechanisms underlying phage exclusion is relevant to i) define the molecular basis of phage typing in surveillance ii), understand of how pathogens evolve, and iii) provide underpinning knowledge relevant to phage therapy.