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How cells talk to each other

细胞如何相互交谈

基本信息

批准号：
1771316
负责人：
金额：
--
依托单位：
University of East Anglia
依托单位国家：
英国
项目类别：
Studentship
财政年份：
2016
资助国家：
英国
起止时间：
2016 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=studentship-1771316
关键词：
How cells talk each other

项目摘要

Plants are sessile organisms that have developed integrated and sophisticated signalling systems to respond to their environment. Plant cells are immobile and thus must relay information between cells and tissues by the deployment of mobile molecules or propagating signalling cascades. By such mechanisms plants can activate a stress response far from the site of detection, leading to changes in gene expression in cells that have not yet but are likely to encounter the stress. In this way, a tissue in a leaf can be primed for defence following detection of a pathogen in a different leaf or the root.One mechanism by which plants signal between distal tissues is by the propagation of calcium waves. Models exist which suggest that a combination of calcium ions and reactive oxygen species work in partnership to propagate this signal, but this requires further testing as recent data suggests some of the underlying assumptions are incorrect. In particular, the role of plasmodesmata (membrane-lined cytoplasmic connections between the cells) and the signalling distance of both classes of molecules in the absence of propagation need further investigation. This project will use state-of-the-art imaging technologies to investigate the role of plasmodesmata (membrane-lined cytoplasmic connections between the cells), and the signalling distance of reactive oxygen species and calcium ions, to establish the mechanisms underlying long distance calcium signalling in plants. Mathematical modelling will be used (in collaboration) to integrate this information to form testable predictions to guide further hypotheses and experimentation.

植物是固着的有机体，它们已经形成了集成和复杂的信号系统来对环境做出反应。植物细胞是不能移动的，因此必须通过部署移动分子或传播信号级联在细胞和组织之间传递信息。通过这种机制，植物可以激活远离检测位置的应激反应，导致尚未但可能遇到逆境的细胞的基因表达发生变化。通过这种方式，在检测到不同叶片或根中的病原体后，叶片中的组织可以为防御做好准备。植物远端组织之间的信号传递机制之一是通过钙波的传播。现有的模型表明，钙离子和活性氧物种的组合共同作用来传播这一信号，但这需要进一步的测试，因为最近的数据表明，一些潜在的假设是不正确的。特别是，胞间连丝(细胞间有膜的胞质连接)的作用以及这两类分子在没有繁殖的情况下的信号距离需要进一步研究。这个项目将使用最先进的成像技术来研究胞间连丝(细胞之间的膜衬里细胞质连接)的作用，以及活性氧和钙离子的信号距离，以建立植物中长距离钙信号的机制。将使用数学模型(合作)来整合这些信息，以形成可检验的预测，以指导进一步的假设和实验。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Chitin perception in plasmodesmata identifies subcellular, context-specific immune signalling in plants

DOI：
10.1101/611582
发表时间：
2019-04
期刊：
bioRxiv
影响因子：
0
作者：
Cécilia Cheval;M. Johnston;Sebastian Samwald;Xiaokun Liu;Annalisa Bellandi;A. Breakspear;Y. Kadota;C. Zipfel;C. Faulkner
通讯作者：
Cécilia Cheval;M. Johnston;Sebastian Samwald;Xiaokun Liu;Annalisa Bellandi;A. Breakspear;Y. Kadota;C. Zipfel;C. Faulkner

The Hyaloperanospora arabidopsidis effector HaRxL77 is hypermobile between cells and manipulates host defence