MODULATION OF NEURONAL RESPONSES IN SOMATOSENSORY CORTEX

体感皮层神经元反应的调节

• 批准号: 6393517
• 负责人: Harold Burton
• 金额: $ 39.21万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6393517
• 关键词: Macaca mulatta; attention; behavioral /social science research tag; brain mapping; clinical research; fingers; frontal lobe /cortex; functional magnetic resonance imaging; human subject; neural information processing; psychobiology; sensory discrimination; sensory thresholds; short term memory; single cell analysis; somesthetic sensory cortex; touch; vibration perception

DESCRIPTION: (Adapted from the Investigator's Abstract) In tactile object recognition we attend to and remember selected features sequentially touched while integrating the information leading to recognition. To understand this complex process we propose using whole-brain functional magnetic resonance imaging (fMRI) in humans and single neuron recording studies in monkeys, who are trained on tactile memory tasks, to investigate the functional anatomy of the sensory and cognitive processes underlying tactile attention and memory. We propose five interrelated fMRI experiments that will determine: (a) the extent of primary somatosensory cortex dedicated to selective activation of the receptors in each fingertip (Exps 1-2), (b) the network of cortical areas engaged by the cognitive processes of tactile attention (Exps 3-4), and (c) the network associated with tactile memory (Exp 5). The first two experiments test the hypothesis that attention involves dynamic modulation of recorded somatotopic maps. The second two experiments focus on the nature of the functional anatomy engaged by attention to the stimulus attributes of vibration frequency, surface roughness and tactile stimulus duration. The fifth experiment examines the functional anatomy engaged during a working memory task for vibration frequency. Overlapping foci identified in Exps 3-5 will suggest a possible network for tactile object recognition because these regions will be common to memory and attention processes. Two neurophysiology studies (Exps 6a, 6b) will record the neural correlates of sensory and working memory in frontal and somatosensory cortex, areas likely to be identified in the fMRI studies. Thus, these observations of single neurons will show differential activity during delay intervals for remembered tactile stimuli and, therefore, highlight the likely temporal dynamics underlying the functional anatomy in the human studies.

描述：（改编自研究者的摘要） 在触觉物体识别中，我们关注并记住选定的特征 依次触摸，同时整合导致识别的信息。 为了理解这个复杂的过程，我们建议使用全脑功能 人类磁共振成像（fMRI）和单神经元记录研究 在接受过触觉记忆任务训练的猴子中，研究 触觉基础的感觉和认知过程的功能解剖学 注意力和记忆力。 我们提出了五个相互关联的功能磁共振成像实验，这些实验将确定：（a） 初级体感皮层的范围致力于选择性激活 每个指尖的受体（实验 1-2），(b) 皮质区域网络 触觉注意的认知过程（实验 3-4），以及 (c) 与触觉记忆相关的网络（实验 5）。前两个实验测试 注意力涉及记录的动态调制的假设 体位图。后两个实验的重点是 功能解剖学关注振动的刺激属性 频率、表面粗糙度和触觉刺激持续时间。第五 实验检查工作记忆任务期间的功能解剖 为振动频率。实验 3-5 中确定的重叠焦点将建议 触觉物体识别的可能网络，因为这些区域将 记忆和注意力过程共有。 两项神经生理学研究（实验 6a、6b）将记录以下神经相关性： 额叶和体感皮层的感觉和工作记忆，这些区域可能 在功能磁共振成像研究中被识别。因此，这些对单个神经元的观察 将在延迟间隔期间显示记忆触觉的差异活动 刺激，因此，强调了潜在的时间动态 人体研究中的功能解剖学。