MIDLINE GLIA AND THE DEVELOPMENT OF THE CORPUS CALLOSUM

中线胶质细胞和胼胝体的发育

• 批准号: 6393974
• 负责人: Linda J Richards
• 金额: $ 23.88万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6393974
• 关键词: axon; cell population study; chemoattractants; corpus callosums; developmental neurobiology; gene expression; gene targeting; genetically modified animals; glia; growth cones; hippocampus; laboratory mouse; membrane proteins; mixed tissue /cell culture; molecular cloning; mutant; neuroanatomy; neuronal guidance; phenotype; prosencephalon; reagent /indicator; receptor; transcription factor

DESCRIPTION (Adapted from the applicant's abstract): This application proposes to examine the role that three glial cell populations play in the development of the corpus callosum. One of these populations form the glial sling, a group of cells that underlie the corpus callosum forming a "bridge" between the two hemispheres. Two newly discovered populations are the glial wedge, a group of cells near the midline that are proposed to deflect cortical axons medially and the indusium griseum, a group of glial cells located dorsal to the callosum. The three specific aims proposed in this new application are as follows: (1) characterize the role Emx1 plays in regulating the expression of guidance molecules derived from the glial sling; (2) determine whether two other midline glial populations are also important for midline guidance of cortical axons; and (3) examine the development of midline glial cells in mouse mutants exhibiting an acallosal phenotype i.e. the netrin-1 and DCC mutant mice.

描述(改编自申请人的摘要)：本申请提出 研究三种神经胶质细胞群在发育中的作用 结缔组织的位置。这些种群中的一个形成了神经胶质吊索，一个群体 形成了两者之间的一座“桥梁” 半个半球。两个新发现的种群是神经胶质楔形，一组 中线附近的细胞被认为使皮质轴突内侧偏转，并 灰质束是位于骨痂背侧的一组神经胶质细胞。 这项新申请提出的三个具体目标如下：(1) 描述Emx1在调节引导表达中的作用 来自神经胶质吊带的分子；(2)确定另外两条中线 神经胶质细胞群对皮质轴突的中线引导也很重要； 以及(3)检测突变小鼠的中线神经胶质细胞的发育 表现为无足细胞表型，即netrin-1和DCC突变小鼠。