MIDLINE GLIA AND THE DEVELOPMENT OF THE CORPUS CALLOSUM

中线胶质细胞和胼胝体的发育

• 批准号: 6540003
• 负责人: Linda J Richards
• 金额: $ 24.59万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6540003
• 关键词: axon; cell population study; chemoattractants; corpus callosums; developmental neurobiology; gene expression; gene targeting; genetically modified animals; glia; growth cones; hippocampus; laboratory mouse; membrane proteins; mixed tissue /cell culture; molecular cloning; mutant; neuroanatomy; neuronal guidance; phenotype; prosencephalon; reagent /indicator; receptor; transcription factor

DESCRIPTION (Adapted from the applicant's abstract): This application proposes to examine the role that three glial cell populations play in the development of the corpus callosum. One of these populations form the glial sling, a group of cells that underlie the corpus callosum forming a "bridge" between the two hemispheres. Two newly discovered populations are the glial wedge, a group of cells near the midline that are proposed to deflect cortical axons medially and the indusium griseum, a group of glial cells located dorsal to the callosum. The three specific aims proposed in this new application are as follows: (1) characterize the role Emx1 plays in regulating the expression of guidance molecules derived from the glial sling; (2) determine whether two other midline glial populations are also important for midline guidance of cortical axons; and (3) examine the development of midline glial cells in mouse mutants exhibiting an acallosal phenotype i.e. the netrin-1 and DCC mutant mice.

描述（改编自申请人的摘要）：本申请提出 研究三种神经胶质细胞群在发育中的作用， 胼胝体其中一个群体形成神经胶质吊索， 胼胝体下面的细胞在两者之间形成了一座“桥梁”， 半球两个新发现的群体是胶质楔，一组 中线附近的细胞，被建议向内侧偏转皮质轴突， 灰被，一组位于胼胝体背侧的胶质细胞。 这项新申请提出的三个具体目标如下：（1） 描述Emx 1在调节引导表达中的作用 分子来源于神经胶质吊索;（2）确定是否有两个其他中线 神经胶质细胞群对于皮质轴突的中线引导也很重要; 以及（3）检查突变小鼠中线胶质细胞的发育 表现出无胼胝体表型，即netrin-1和DCC突变小鼠。