Seasonal Adaptation of a Circadian Clock

昼夜节律钟的季节适应

基本信息

  • 批准号:
    6361103
  • 负责人:
  • 金额:
    $ 26.32万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2001
  • 资助国家:
    美国
  • 起止时间:
    2001-07-15 至 2005-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this proposal is to understand how a circadian clock (or pacemaker) accommodates new phase alignments in response to seasonal changes in ambient temperature and daylength (photoperiod), a topic that has received little attention from a molecular perspective. This feature of circadian clocks has immense biological significance because it enables organisms to (1) adopt optimal phase-alignments between physiological and behavioral rhythms and the prevailing environmental conditions, and (2) trigger seasonally appropriate responses. A major foundation for the proposed specific aims in this application is based on our recent published work [Majercak et al., (1999) Neuron, 24:219] showing that the thermosensitive splicing of the 3-terminal intron from the D. melanogaster period (dper) RNA (herein refereed to as dmpi8; D. melanogaster dper intron 8) makes a major contribution to the preferential daytime activity of this species during seasonally cold days. Recent findings indicate that whereas the splicing efficiency of dmpi8 is stimulated by cold temperatures, light inhibits this splicing event, demonstrating intricate multi-modal regulation. Our findings suggest that the thermal and photoperiodic regulation of dmpi8 splicing acts as a "seasonal sensor" conveying calendar information to the animal. In this application we propose to determine how temperature and light co-regulate the splicing efficiency of dmpi8. No only will these studies investigate a novel effect of light on the D. melanogaster circadian clock but our recent findings implicate a new role for the visual signal transduction cascade in the phase control of activity rhythms driven from deep brain pacemaker cells. Moreover, we will analyze the clockworks and behavioral rhythms in several Drosophila species from a wide range of latitudinal gradients. These studies might reveal a role for natural selection in the adaptation of circadian clocks to geographical variations in seasonal climates. To accomplish these goals we propose to take multifacted experimental strategies including in vitro biochemical, tissue culture and whole animal approaches. With the recent realization that the basic molecular logic underlying circadian clocks from a wide variety of organisms, including humans, is conserved, it is anticipated that although specific details will differ our investigation of how a circadian clock integrates multiple environmental modalities will lead to general principles that are applicable to a wide range of circadian systems.
描述(由申请人提供):本提案的总体目标是 了解生物钟(或起搏器)如何适应新的相位 响应环境温度和日照长度季节变化的路线 (光周期),一个很少受到分子关注的话题 perspective.生物钟的这一特征具有巨大的生物学意义。 重要性,因为它使生物体(1)采用最佳相位对齐 生理和行为节律与环境之间的联系 (2)季节性的反应。一个主要 本申请中提出的具体目标的基础是基于我们的 最近发表的工作[Majercak等人,(1999)Neuron,24:219]显示, 温度敏感性剪接的3-末端内含子从D. melanogaster period(dper)RNA(本文称为dmpi 8; D.黑腹果蝇dper内含子8) 对这个物种的白天活动做出了重大贡献 在季节性寒冷的日子里。最近的研究结果表明,尽管剪接 DMPI 8的效率受低温刺激,光抑制这一点 剪接事件,展示了复杂的多模式调节。我们的研究结果 表明DMPI 8剪接的热和光周期调节作为 一个“季节传感器”,将日历信息传递给动物。在这 应用,我们建议确定温度和光如何共同调节 DMPI的剪接效率8.这些研究不仅会调查一部小说 光照对D.但我们最近的发现 暗示了视觉信号转导级联的新作用, 控制由脑深部起搏细胞驱动的活动节律。此外,委员会认为, 我们将分析几种果蝇的时钟机制和行为节奏, 物种从一个广泛的纬度梯度。这些研究可能揭示 自然选择在生物钟适应 季节性气候的地理变化。为了实现这些目标,我们 建议采取多因素的实验策略,包括体外 生物化学、组织培养和整体动物方法。随着近期 意识到生物钟背后的基本分子逻辑 包括人类在内的各种生物都是保守的,预计 虽然具体细节会有所不同,但我们对昼夜节律的研究 时钟集成多种环境模式将导致一般 这些原则适用于广泛的昼夜节律系统。

项目成果

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ISAAC EDERY其他文献

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{{ truncateString('ISAAC EDERY', 18)}}的其他基金

Mechanisms Underlying Seasonal Adaptation of Daily Behaviors
日常行为季节性适应的机制
  • 批准号:
    10183348
  • 财政年份:
    2018
  • 资助金额:
    $ 26.32万
  • 项目类别:
Mechanisms Underlying Seasonal Adaptation of Daily Behaviors
日常行为季节性适应的机制
  • 批准号:
    10406158
  • 财政年份:
    2018
  • 资助金额:
    $ 26.32万
  • 项目类别:
Mechanisms Underlying Seasonal Adaptation of Daily Behaviors
日常行为季节性适应的机制
  • 批准号:
    9920226
  • 财政年份:
    2018
  • 资助金额:
    $ 26.32万
  • 项目类别:
Clock Mechanism Underlying Drosophila Rhythmic Behavior
果蝇节律行为的时钟机制
  • 批准号:
    9336138
  • 财政年份:
    2016
  • 资助金额:
    $ 26.32万
  • 项目类别:
Clock Mechanism Underlying Drosophila Rhythmic Behavior
果蝇节律行为的时钟机制
  • 批准号:
    9012966
  • 财政年份:
    2015
  • 资助金额:
    $ 26.32万
  • 项目类别:
Seasonal Adaptation of a Circadian Clock
昼夜节律钟的季节适应
  • 批准号:
    6540508
  • 财政年份:
    2001
  • 资助金额:
    $ 26.32万
  • 项目类别:
Seasonal Adaptation of a Circadian Clock
昼夜节律钟的季节适应
  • 批准号:
    8288134
  • 财政年份:
    2001
  • 资助金额:
    $ 26.32万
  • 项目类别:
Seasonal Adaptation of a Circadian Clock
昼夜节律钟的季节适应
  • 批准号:
    7888920
  • 财政年份:
    2001
  • 资助金额:
    $ 26.32万
  • 项目类别:
Seasonal Adaptation of a Circadian Clock
昼夜节律钟的季节适应
  • 批准号:
    8016560
  • 财政年份:
    2001
  • 资助金额:
    $ 26.32万
  • 项目类别:
Seasonal Adaptation of a Circadian Clock
昼夜节律钟的季节适应
  • 批准号:
    8473922
  • 财政年份:
    2001
  • 资助金额:
    $ 26.32万
  • 项目类别:

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