Characterization and modelling of interactions between complex molecules and lipid bilayer.

这个项目将研究复杂分子与脂质膜相互作用的方式。该项目将涉及具有不同成分的脂质囊泡的表征，以模拟不同的细胞类型。各种复杂分子与脂质囊泡的相互作用将使用一系列生物物理技术进行探索，包括动态光散射、圆形和线性二色性以及分配实验。复杂的分子，脂质双层和两者的相互作用，也将使用从分子动力学到各种粗粒度技术的一系列计算工具进行研究。总体目标是通过实验确定这些系统的特性，然后根据实验结果验证模型，从而在未来改进模型。

This project will investigate the way in which complex molecules interact with lipid membranes. The project will involve the characterization of lipid vesicles with varying compositions to mimic different cell types. The interaction of various complex molecules with lipid vesicles will be explored using a range of biophysical techniques including dynamic light scattering, circular and linear dichroism and partitioning experiments. The complex molecules, the lipid bilayers and the interaction of the two, will also be studied using a range of computational tools from molecular dynamics up through various coarse grained techniques. The overall aim is to experimentally determine the properties of these systems and then validate the modelling against the experimental results leading to improved modelling in the future.