Characterization and modelling of interactions between complex molecules and lipid bilayer.

这个项目将研究复杂分子与类脂膜相互作用的方式。该项目将涉及具有不同成分的脂泡的特征，以模拟不同的细胞类型。各种复杂分子与脂泡的相互作用将使用一系列生物物理技术来探索，包括动态光散射、圆和线性二色性以及分配实验。还将使用从分子动力学到各种粗粒化技术的一系列计算工具来研究复杂分子、脂质双层以及两者之间的相互作用。总体目标是在实验上确定这些系统的特性，然后对照实验结果验证建模，从而在未来改进建模。

This project will investigate the way in which complex molecules interact with lipid membranes. The project will involve the characterization of lipid vesicles with varying compositions to mimic different cell types. The interaction of various complex molecules with lipid vesicles will be explored using a range of biophysical techniques including dynamic light scattering, circular and linear dichroism and partitioning experiments. The complex molecules, the lipid bilayers and the interaction of the two, will also be studied using a range of computational tools from molecular dynamics up through various coarse grained techniques. The overall aim is to experimentally determine the properties of these systems and then validate the modelling against the experimental results leading to improved modelling in the future.