Characterization and modelling of interactions between complex molecules and lipid bilayer.

本项目将研究复杂分子与脂质膜相互作用的方式。该项目将涉及具有不同组成的脂质囊泡的表征，以模拟不同的细胞类型。各种复杂的分子与脂质囊泡的相互作用将探讨使用一系列的生物物理技术，包括动态光散射，圆和线性二色性和分区实验。复杂的分子，脂质双层和两者的相互作用，也将使用一系列的计算工具，从分子动力学通过各种粗粒度的技术进行研究。总体目标是通过实验确定这些系统的特性，然后根据实验结果验证建模，从而在未来改进建模。

This project will investigate the way in which complex molecules interact with lipid membranes. The project will involve the characterization of lipid vesicles with varying compositions to mimic different cell types. The interaction of various complex molecules with lipid vesicles will be explored using a range of biophysical techniques including dynamic light scattering, circular and linear dichroism and partitioning experiments. The complex molecules, the lipid bilayers and the interaction of the two, will also be studied using a range of computational tools from molecular dynamics up through various coarse grained techniques. The overall aim is to experimentally determine the properties of these systems and then validate the modelling against the experimental results leading to improved modelling in the future.