FASEB Research Conference on Biological Methylation

FASEB 生物甲基化研究会议

• 批准号: 6360056
• 负责人: CLARE M O'CONNOR
• 金额: $ 0.8万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-05 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6360056
• 关键词: S adenosylmethionine; catechol methyltransferase; enzyme activity; meeting /conference /symposium; methylation

DESCRIPTION (provided by applicant) This proposal requests partial funding for a conference on "Biological Methylation" to be held from July 21-26, 2001, at the Vermont Academy in Saxtons River, Vermont. This will be the fifth biennial conference on this topic, which is held under the auspices of the Federation of American Societies for Experimental Biology (FASEB). The Biological Methylation Conference is unique in its integrative treatment of AdoMet-dependent methyltransferases, biological processes affected by methylation, and AdoMet metabolism. New methyltransferases are being identified at accelerating rates as genomics data becomes available, and identified substrates for the methyltransferases now include DNA, RNAs, proteins, lipids and a large number of small organic molecules. Because of the importance of DNA methylation to the control of gene expression and chromosomal stability, approximately half of the meeting's sessions are focused on aspects of DNA methylation, with particular emphasis on its role in carcinogenesis. Other topics include protein methyltransferases, structural studies of methyltransferases, AdoMet metabolism and drug design. The meeting is attended by a diverse group of junior and senior scientists from a range of academic, clinical and industrial institutions. A major goal of the meeting is to promote interactions between scientists studying particular methylation reactions at the molecular, cellular and physiological levels. The conference format includes six plenary sessions (24 speakers) and a series of eight less formal minisymposia (24 speakers). Speakers include both established and junior investigators. Each plenary session will include an expert overview of the selected topic and three presentations selected for their novelty and high impact on the field. Minisymposia are designed with a more restrictive focus on cutting-edge or controversial topics. The last evening will include a moderated discussion session of posters selected for presentation by a panel of senior investigators. Posters will be displayed continuously at the meeting to maximize the potential for informal interactions and discussion of data between the attendees. The 2001 meeting is expected to attract 140-150 scientists, largely from domestic institutions.

描述（由申请人提供） 该提案要求部分资助 将于2001年7月21日至26日举行的“生物甲基化”会议， 位于佛蒙特州萨克斯顿河的佛蒙特学院。 这将是第五次 关于这一主题的每两年一次的会议，是在 美国实验生物学会联合会 (FASEB)。 这 生物甲基化会议的独特之处在于它的综合治疗 AdoMet 依赖性甲基转移酶，受其影响的生物过程 甲基化和 AdoMet 代谢。 新的甲基转移酶正在开发中 随着基因组学数据的出现，识别速度会加快，并且 现在已确定的甲基转移酶底物包括 DNA、RNA、 蛋白质、脂质和大量有机小分子。 由于 DNA甲基化对基因表达控制的重要性 染色体稳定性，大约一半的会议是 重点关注 DNA 甲基化的各个方面，特别强调其在 致癌作用。 其他主题包括蛋白质甲基转移酶、结构 甲基转移酶、AdoMet 代谢和药物设计的研究。 会议 参加会议的有来自不同领域的初级和高级科学家 学术、临床和工业机构。 会议的一个主要目标 是促进研究特定甲基化的科学家之间的互动 分子、细胞和生理水平的反应。 会议 形式包括六场全体会议（24 位发言者）和一系列八场以下的会议 正式小型研讨会（24 名发言者）。 演讲者包括知名人士和 初级调查员。 每次全体会议将包括专家概述 所选主题和三个演讲因其新颖性和高水平而被选中 对场上的影响。 小型研讨会的设计重点更加严格 关于前沿或有争议的话题。 最后一个晚上将包括 由小组主持的海报讨论会 的高级调查员。 海报将在现场持续展示 会议以最大限度地发挥非正式互动和讨论的潜力 与会者之间的数据。 2001年的会议预计将吸引140-150人 科学家，主要来自国内机构。