FASEB CONFERENCE--NUCLEAR STRUCTURE AND CANCER

FASEB 会议——核结构与癌症

• 批准号: 6360018
• 负责人: Gary S. Stein
• 金额: $ 1万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6360018
• 关键词: DNA replication; cell nucleus; chromosomes; gene induction /repression; meeting /conference /symposium; neoplasm /cancer genetics; nuclear matrix; nucleic acid structure; transcription factor

DESCRIPTION (provided by applicant) This application is for partial funding of the 2001 FASEB Summer Conference on "Nuclear Structure and Cancer" to be held on August 11-16 at the Vermont Academy in Saxtons River, Vermont. The conference is under the auspices of the Federation of American Societies for Experimental Biology (FASEB). There will be 9 oral sessions, each including short presentations by young investigators. There will be a 2 poster sessions, each followed by round table discussions. This conference will provide a forum to evaluate the fundamental regulatory and clinical implications of modified organization of nucleic acids and regulatory proteins that control gene replication and expression in nuclei of tumor cells. The importance of tumor-related changes in nuclear morphology and the subnuclear organization or regulatory factors is becoming increasingly recognized. However, this will be the first meeting that will focus on perturbations of nuclear structure-gene expression interrelationships that are linked to cancer. There is a requirement for a conference that is dedicated to examining the structural and functional properties of cells that are compromised with the onset and progression of cancer. Cause and effect relationships between nuclear morphology and gene replication as well as gene expression will be systematically explored. There will be a concerted effort to critically evaluated findings that interface nuclear structure and function. Consideration will be given to contributions from cellular, biochemical, genetic, and molecular approaches. The meeting will address experimental strategies and high resolution methodologies for defining alterations in gene replication and expression that are associated with cancer from the perspective of the organization of nucleic acids and regulatory proteins within nuclei.

描述（由申请人提供） 该申请是针对2001年Faseb夏季会议的部分资金 将于8月11日至16日在佛蒙特州举行的“核结构和癌症” 佛蒙特州萨克斯顿河的学院。 会议是在 美国实验生物学联合会（FASEB）。 那里 将是9次口腔会议，每个会议包括Young的简短演讲 调查人员。 将有2个海报会议，每个海报接下来是圆 表讨论。 该会议将提供一个论坛来评估基本监管 以及修饰的核酸组织的临床意义和 控制基因复制和表达在核中的调节蛋白 肿瘤细胞。 与肿瘤相关的核形态变化的重要性 核下组织或监管因素正变得越来越多 认可。 但是，这将是第一次关注的会议 核结构 - 基因表达相互关系的扰动 与癌症有关。 有专门的会议要求 检查细胞的结构和功能特性 因癌症的发作和进展而妥协。 因果 核形态和基因复制与基因之间的关系 表达式将被系统探索。 会有一致的努力 批判性评估的发现核结构和 功能。 将考虑细胞的贡献， 生化，遗传和分子方法。 会议将解决 定义的实验策略和高分辨率方法 与癌症相关的基因复制和表达的改变 从核酸和调节的组织的角度来看 核中的蛋白质。