Gravitational Effects on Living Systems: Mechanosensing

重力对生命系统的影响：机械传感

• 批准号: 6359876
• 负责人: Ruth Anne Eatock
• 金额: $ 2.88万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359876
• 关键词: gravity; mechanoreceptors; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): The seventh biennial Gordon Research Conference on Gravitational Effects on Living Systems will be held July 1-6, 2001 at Connecticut College. The theme of the meeting is mechanosensing, an ancient sensory capability. Approximately 100 participants are expected, including 23-25 speakers and 13 discussion leaders. The participation of trainees will be actively sought. While gravity affects living systems in many ways, mechanosensing is an appropriate focus for the meeting. Gravity is detected by mechanosen-sors, but most importantly for the meeting's success, this is an exciting and critical time for research on mechanosensors. The crystal structure of a prokaryotic mechanosensitive channel has recently been elucidated. Behavioral screens of eukaryotic genetic model animals, the yeast, roundworm and fruitfly, have yielded different mechanosensory cascades, including two putative classes of mechanosensory ion channels. Strong functional parallels have recently been shown between the mechanosensory chordotonal organs of flies and the sensory hair cells of the vertebrate inner ear. Intense genetic scrutiny of the mammalian inner ear has produced several pivotal successes in identifying genetic mutations underlying inner ear pathology in mice and humans. In addition to such work on specialized mechanosensors, there have been major recent advances in understanding the responses of nonmechanosensory tissues (muscle, bone, shoots and roots of plants) to mechanical input. The proposed meeting will bring together scientists who don't normally have a chance to meet either because they study different kinds of organisms (microorganisms, plants or animals), or different kinds of mechanical responses (mechanically evoked cascades in specialized mechanosensors vs. tissues that re- model in response to mechanical inputs, including gravity), or because they take widely different approaches (physiology vs. genetics). Moreover, the Gordon Conference format facilitates informal communications and discussions of controversial issues. These factors will promote inter-disciplinary transfer of ideas and approaches and the generation of new strategies for the study of mechanotransduction.

描述（由申请人提供）：第七届戈登研究双年展 引力对生命系统影响会议将于 7 月 1 日至 6 日举行， 2001年在康涅狄格学院。 会议的主题是机械传感 古老的感官能力。预计参加人数约100人， 包括 23-25 名演讲者和 13 名讨论主持人。 的参与 将积极寻找实习生。 虽然重力以多种方式影响生命系统，但机械传感是一种 会议的适当焦点。 重力是由机械传感器检测到的，但是 对于会议的成功最重要的是，这是一次令人兴奋和关键的会议 是时候研究机械传感器了。 原核生物的晶体结构 机械敏感通道最近已被阐明。行为屏幕 真核遗传模型动物，酵母、蛔虫和果蝇，具有 产生了不同的机械感觉级联，包括两类假定的 机械感觉离子通道。最近有很强的功能相似之处 显示在苍蝇的机械感觉弦音器官和感觉器官之间 脊椎动物内耳的毛细胞。 严格的基因检查 哺乳动物内耳在识别 小鼠和人类内耳病理的基因突变。 在 除了专门的机械传感器方面的工作外，还有一些重大的工作 了解非机械感觉组织反应的最新进展 （植物的肌肉、骨骼、芽和根）到机械输入。 拟议的会议将汇集通常没有会议的科学家 有机会见面，因为他们研究不同种类的生物体 （微生物、植物或动物）或不同种类的机械反应 （在专门的机械传感器与组织中机械诱发的级联反应 模型响应机械输入，包括重力），或者因为它们采取 截然不同的方法（生理学与遗传学）。 此外，戈登 会议形式有利于非正式沟通和讨论 有争议的问题。这些因素将促进跨学科转移 思想和方法以及新研究策略的产生 力传导。