FASEB SUMMER RESEARCH CONFERENCE: TRANSPORT ATPASES

FASEB 夏季研究会议：运输ATP酶

• 批准号: 6359997
• 负责人: PETER L PEDERSEN
• 金额: $ 1.15万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359997
• 关键词: adenosinetriphosphatase; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): This is an application for partial funding of a summer research conference entitled "Transport ATPases: From Genomics to Mechanism" to be held in Snowmass, Colorado from July 14-19, 2001. This conference which has been previously reviewed and approved by the FASEB committee on summer research conferences is the third such conference on transport ATPases, the previous 2 being held in 1997 and 1999 in Copper Mountain, and Snowmass, Colorado, respectively. The major goal of this meeting is to bring together about 150 scientists throughout the world working on transport ATPases in order to share new information and ideas about this increasingly important area. Specifically, this conference, via about 50 talks, 100 posters, and both informal and organized discussions, will disseminate new information about transport ATPases ranging from genomics to mechanism as implied by the title. The date of the conference is very timely as it will capitalize on a number of recent achievements including the completion of the sequencing of the human genome, the resolution of several transport ATPase structures (F and P-type) at atomic resolution, and the discovery of several new transport ATPases of considerable medical significance. The conference includes 7 session with topics as follows: 1) Genomics of transport ATPases; 2) P-type ATPases I (Calcium ATPases); 3) P-type ATPases II (proton, proton/potassium, and sodium/potassium ATPases); 4) F-type ATPases; 5) V-type ATPases; 6) ABC transporters; and 7) new, or relatively unique, ATPase-dependent transporters or channels. This is the only established conference in the world focused entirely on transport ATPases. The new information that will be discussed at this meeting is directly relevant at a very basic level to how a wide variety of ions, metabolites, and drugs move across biological membranes of animals, plants, and bacteria, and how the energy of ATP hydrolysis is coupled to this movement. This meeting will be particularly exciting because for the first time much basic work on ATPases can be interpreted and further guided by new structural data on the one hand and new genomic data on the other. Noteworthy, is the fact that the very timely work to be reported at this meeting has far reaching medical/clinical implication directly related to the missions of a number of NIH institutes including the NIGMS (all transport ATPases), NHBLI (calcium and sodium/potassium ATPases and ABCA 1), NIDDK (CFTR, SUR, proton/potassium, and copper ATPases), NCI (MDR /P-glycoprotein and MRP 1), and the NEI (ABCR). Specific disease or clinical relevance, include cardiac failure or hypertrophy, hypercholesterolemia, cystic fibrosis, diabetes, gastric ulcers, Menke's disease, Wilson's disease, Stargardt's disease, and drug resistance associated with the treatment of cancer, AIDS, and numerous other diseases. There is a good representation among the speakers of established and junior scientists, both male and female.

描述（由申请人提供）： 这是一份夏季研究会议部分资金的申请 题为“运输ATP酶：从基因组学到机制”， 2001年7月14日至19日，科罗拉多斯诺马斯。这次会议， 先前由FASEB夏季研究委员会审查和批准 会议是第三次这样的会议上运输ATPases，前2 1997年和1999年在科罗拉多的铜山和斯诺马斯举行， 分别本次会议的主要目标是汇集约150名 全世界的科学家都在研究运输ATP酶， 关于这个日益重要的领域的新信息和想法。具体地说， 这次会议，通过大约50个会谈，100海报，和非正式和 组织的讨论，将传播有关运输ATPases的新信息 从基因组学到标题所暗示的机制。之日 会议是非常及时的，因为它将利用一些最近的 包括完成人类基因组测序在内的成就， 几种转运ATP酶结构（F型和P型）原子分辨率 解决，并发现了几个新的运输ATP酶的相当大的 医学意义会议包括7个分会场，主题如下： 1)转运ATP酶的基因组学; 2）P型ATP酶I（钙ATP酶）; 3） P型ATP酶II（质子、质子/钾和钠/钾ATP酶）; 4） F型ATP酶; 5）V型ATP酶; 6）ABC转运蛋白;和7）新的，或 相对独特的ATP酶依赖性转运蛋白或通道。这是唯一的 在世界上建立的会议完全集中在运输ATP酶。 这次会议将讨论的新信息与 在一个非常基本的水平上，各种各样的离子，代谢物和药物 在动物、植物和细菌的生物膜上移动， ATP水解的能量与这种运动相结合。这次会议将 特别令人兴奋的是，这是第一次，许多关于ATP酶的基础工作， 一方面，通过新的结构数据进行解释和进一步指导， 另一边是新的基因组数据值得注意的是， 本次会议上报告的工作将广泛影响医学/临床 直接关系到一些国家卫生研究所的使命的影响 包括NIGMS（所有转运ATP酶）、NHBLI（钙和 钠/钾ATP酶和ABCA 1），NIDDK（CFTR，SUR，质子/钾，和 铜ATP酶）、NCI（MDR /P-糖蛋白和MRP 1）和NEI（ABCR）。 特定疾病或临床相关性，包括心力衰竭或肥大， 高胆固醇血症、囊性纤维化、糖尿病、胃溃疡、Menke's 疾病、Wilson病、Stargardt病以及与之相关的耐药性 治疗癌症、艾滋病和许多其他疾病。 在老牌和初级的演讲者中有很好的代表性 科学家，男性和女性。