FASEB SUMMER RESEARCH CONFERENCE: TRANSPORT ATPASES

FASEB 夏季研究会议：运输ATP酶

• 批准号: 6359997
• 负责人: PETER L PEDERSEN
• 金额: $ 1.15万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359997
• 关键词: adenosinetriphosphatase; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): This is an application for partial funding of a summer research conference entitled "Transport ATPases: From Genomics to Mechanism" to be held in Snowmass, Colorado from July 14-19, 2001. This conference which has been previously reviewed and approved by the FASEB committee on summer research conferences is the third such conference on transport ATPases, the previous 2 being held in 1997 and 1999 in Copper Mountain, and Snowmass, Colorado, respectively. The major goal of this meeting is to bring together about 150 scientists throughout the world working on transport ATPases in order to share new information and ideas about this increasingly important area. Specifically, this conference, via about 50 talks, 100 posters, and both informal and organized discussions, will disseminate new information about transport ATPases ranging from genomics to mechanism as implied by the title. The date of the conference is very timely as it will capitalize on a number of recent achievements including the completion of the sequencing of the human genome, the resolution of several transport ATPase structures (F and P-type) at atomic resolution, and the discovery of several new transport ATPases of considerable medical significance. The conference includes 7 session with topics as follows: 1) Genomics of transport ATPases; 2) P-type ATPases I (Calcium ATPases); 3) P-type ATPases II (proton, proton/potassium, and sodium/potassium ATPases); 4) F-type ATPases; 5) V-type ATPases; 6) ABC transporters; and 7) new, or relatively unique, ATPase-dependent transporters or channels. This is the only established conference in the world focused entirely on transport ATPases. The new information that will be discussed at this meeting is directly relevant at a very basic level to how a wide variety of ions, metabolites, and drugs move across biological membranes of animals, plants, and bacteria, and how the energy of ATP hydrolysis is coupled to this movement. This meeting will be particularly exciting because for the first time much basic work on ATPases can be interpreted and further guided by new structural data on the one hand and new genomic data on the other. Noteworthy, is the fact that the very timely work to be reported at this meeting has far reaching medical/clinical implication directly related to the missions of a number of NIH institutes including the NIGMS (all transport ATPases), NHBLI (calcium and sodium/potassium ATPases and ABCA 1), NIDDK (CFTR, SUR, proton/potassium, and copper ATPases), NCI (MDR /P-glycoprotein and MRP 1), and the NEI (ABCR). Specific disease or clinical relevance, include cardiac failure or hypertrophy, hypercholesterolemia, cystic fibrosis, diabetes, gastric ulcers, Menke's disease, Wilson's disease, Stargardt's disease, and drug resistance associated with the treatment of cancer, AIDS, and numerous other diseases. There is a good representation among the speakers of established and junior scientists, both male and female.

描述(由申请人提供)： 这是一个夏季研究会议的部分资金申请。 题为《运输ATPase：从基因组学到机制》的展览将在北京举行 2001年7月14日至19日，科罗拉多州斯诺马斯。这次会议已经举行了 以前由FASEB夏季研究委员会审查和批准 会议是关于运输ATPase的第三次这样的会议，前两次 于1997年和1999年在科罗拉多州的铜山和斯诺马斯举行， 分别进行了分析。这次会议的主要目标是召集大约150人 世界各地的科学家致力于运输ATPase，以便分享 关于这一日益重要的领域的新信息和新想法。具体来说， 这次会议，通过大约50次演讲，100张海报，以及非正式和 有组织的讨论，将传播有关交通ATPase的新信息 从基因组学到标题所暗示的机制。事件的日期 会议非常及时，因为它将利用最近的一些 取得的成就包括完成人类基因组测序， 几种转运型ATPase结构(F型和P型)的原子分辨 分辨率，并发现了几个新的具有重要意义的运输ATPase 医学上的意义。大会包括7场会议，议题如下： 1)转运型ATPase基因组学；2)P型ATPase I(钙ATPase)；3) P型ATPase II(质子、质子/钾和钠/钾)；4) F型ATPase；5)V型ATPase；6)ABC转运蛋白；以及7)新的，或 相对独特的、依赖于ATPase的转运体或通道。这是唯一的 世界上公认的会议完全集中在运输ATPase上。 将在这次会议上讨论的新信息直接相关 在非常基本的水平上，各种各样的离子、代谢物和药物 跨越动物、植物和细菌的生物膜，以及 ATP水解的能量与这一运动相耦合。这次会议将是 特别令人兴奋，因为许多关于ATPase的基础工作第一次可以 一方面在新的结构性数据的解读和进一步指导下， 另一方面是新的基因组数据。值得注意的是，这一事实非常及时 将在这次会议上报告的工作具有深远的医学/临床意义 与许多NIH研究所的任务直接相关的影响 包括NIGMS(所有转运ATPase)、NHBLI(钙和 钠/钾ATPase和ABCA 1)、NIDDK(CFTR、SUR、质子/钾和 铜ATPase)、NCI(MDR/P-糖蛋白和MRP-1)和NEI(ABCR)。 特定疾病或临床相关性，包括心力衰竭或肥厚， 高胆固醇血症、囊性纤维化、糖尿病、胃溃疡、门克氏病 疾病、肝豆状核变性、斯塔加德氏病与耐药性相关 治疗癌症、艾滋病和许多其他疾病。 在老牌和初级演讲者中有很好的代表性 科学家，包括男性和女性。