Gordon Conference--Epigenetic Effects of Gene Expression

描述（由申请人提供） 这项建议要求支持戈登研究会议的表观遗传 基因表达的调节将在新罕布什尔州的霍尔顿学校举行， 2001年8月12日至17日。 表观遗传调控是由创造和 染色质中可遗传但可能可逆的变化的维持 结构和/或DNA甲基化，其改变基因表达而不改变 DNA序列 表观遗传效应已在许多生物体中发现， 它们包含了一些最有趣和最活跃的研究现象 与基础科学和应用科学都相关。 例如，表观遗传 转基因的沉默对转基因的长期商业应用造成了问题。 转基因植物被工程化以表达新的表型， 人类基因治疗试验 此外，表观遗传印记事件的丢失 在染色体上的突变会导致多种人类癌症。 此外，本发明还提供了一种方法， 编码DNA甲基转移酶的基因突变和甲基-DNA结合 蛋白质导致人类疾病，即ICF综合征和Rett综合征， 分别 在理解分子生物学方面已经取得了进展， 在过去的几年里，表观遗传沉默的基础机制， 将是这次会议的一个主要焦点。 特邀演讲嘉宾引领 研究真菌、植物和动物模型的研究人员， 如DNA甲基化控制和功能、基于染色质的基因 沉默，转录后基因沉默，印记，X-失活， 朊病毒，表观遗传学和疾病，基因组防御系统，副突变和 位置效应。 表观遗传学戈登会议提供了一个独特的 研究人员在不同领域研究相关现象的机会 生物聚集在一起，交流最近的成果和想法。 它处于 像这样的跨学科环境，智力飞跃发生， 创新思想蓬勃发展。

DESCRIPTION (provided by applicant) This proposal requests support for a Gordon Research Conference on Epigenetic Regulation of Gene Expression to be held at Holderness School, New Hampshire, August 12-17, 2001. Epigenetic regulation is mediated by the creation and maintenance of heritable, but potentially reversible, changes in chromatin structure and/or DNA methylation which alters gene expression without altering DNA sequence. Epigenetic effects have been discovered in many organisms and they comprise some of the most intriguing and actively investigated phenomena with relevance to both basic and applied science. For example, epigenetic silencing of transgenes poses problems for the long term, commercial use of transgenic plants engineered to express novel phenotypes and can complicate human gene therapy trials. Moreover, loss of epigenetically imprinted events on the chromosome are shown to cause many human cancer types. In addition, mutations in genes encoding DNA methyltransferase and a methyl-DNA binding protein lead to diseases in humans, namely ICF syndrome and Rett Syndrome, respectively. Advances have been made towards understanding the molecular mechanisms that underlie epigenetic silencing in the last few years and this will be a major focus of this conference. Invited speakers are leading researchers working on fungal, plant and animal models who will cover topics such as control and function of DNA methylation, chromatin-based gene silencing, post-transcriptional gene silencing, imprinting, X-inactivation, prions, epigenetics and disease, genome defense systems, paramutation and position effects. The Epigenetics Gordon Conference provides a unique opportunity for researchers working on related phenomena in different organisms to come together and exchange recent results and ideas. It is in a cross-disciplinary environment such as this that intellectual leaps occur and innovative ideas flourish.