How does the chromatin remodeller CHD4 regulate gene expression?

染色质重塑因子 CHD4 如何调节基因表达？

• 批准号: DP240102119
• 负责人: Prof Joel Mackay
• 金额: $ 53.6万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2027-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102119
• 关键词: How; does; chromatin; remodeller; CHD4

The mechanisms that determine how genes are switched on and off in different tissues and at different times are in many ways still mysterious. It is well established that gene expression patterns in complex organisms are determined in part by the manner in which DNA is physically packaged. Our aim is to define new aspects of these mechanisms that revolve around molecular motors that regulate DNA packaging. This foundational knowledge will deepen our understanding of gene regulation in all complex organisms and will inform future efforts to rationally modulate gene expression patterns in agriculture, research and other important areas.

在许多方面，决定基因在不同组织和不同时间如何开启和关闭的机制仍然是神秘的。众所周知，复杂生物体中的基因表达模式部分取决于DNA的物理包装方式。我们的目标是定义这些机制的新方面，这些机制围绕着调节DNA包装的分子马达。这些基础知识将加深我们对所有复杂生物体中基因调控的理解，并将为未来在农业，研究和其他重要领域合理调节基因表达模式的努力提供信息。