2001 Gordon Research Conference on Bioenergetics

描述（由申请人提供）：生物能学戈登会议是 会议每半年举行一次，上一次会议于1999年6月举行。最大的（CA）500 上周结束的欧洲生物能量学大会在 每隔一年。传统上，生物能量学GRC强调 电子传递和氧化磷酸化机制的讨论， 沿着对线粒体的生物医学意义的讨论 肌病和衰老。然而，作为第一高分辨率的大多数， 从能量转换中获得了完整的膜蛋白结构 膜，本次会议已成为一个重要的平台，讨论 完整膜蛋白生物化学。基于结构的机制讨论 涉及膜蛋白的整合已经成为了 生物能量学GRC，以及在这一前沿领域的贡献是一个主要的 规划和组织届会的标准。因此 去年确定的高分辨率（1.55 A）结构， 细菌视紫红质，最高分辨率的膜蛋白结构，沿着 用盐视紫红质和视紫红质的高分辨率结构， 一个很好的机会，比较介绍和讨论的 视紫红质家族的结构和进化。本方案还将 有关于主动运输和生物发生的主要会议。 戈登会议的非正式性和自发性的特点允许 深入讨论基本问题的可能性。进一步 在可行的情况下，鼓励本会议进行这种讨论， 是围绕概念性主题组织的，而不是专注于个人 蛋白质或实验系统。这是一个实验，但我相信 会很有趣的。 本申请所要求拨款的主要用途，是资助 参加这次会议的“年轻”人，研究生和 博士后46名学生和博士后，在总共145人中， 出席了最后一次会议。研究发现， 光谱学方法和膜整合蛋白的定量分析 使教育成为必要，并告知有兴趣的年轻研究人员， 这个领域的人将成为下一代生物能量学GRC是一个 这是一个非常令人鼓舞的场所。当然，这些想法和 年轻人的研究也对其他人有启发性。 我们

DESCRIPTION (provided by applicant): The Bioenergetics Gordon Conference is convened biannually and was last held in June, 1999. The larger (ca. 500 person) European Bioenergetics Congress, completed last week, is held in the alternate years. Traditionally, the Bioenergetics GRC has emphasized discussions on mechanisms of electron transport and oxidative phosphorylation, along with the discussions of the biomedical implications for mitochondrial myopathies and aging. However, as the majority of the first high resolution structures of integral membrane proteins were obtained from energy-transducing membranes, this Conference has become a major platform for discussions of integral membrane protein biochemistry. Structure-based discussion of mechanism involving integral membrane proteins has now become a basic theme of the Bioenergetics GRC, and contributions in this cutting-edge area are a major criteria in the planning and organization of the sessions. Thus, the determination in the last year of the high resolution (1.55 A) structure of bacteriorhodopsin, the highest resolution membrane protein structure, along with high resolution structures of halorhodopsin and rhodopsin, created a wonderful opportunity for a comparative presentation and discussion of the structures and evolution of the rhodopsin family. The present program will also have major sessions on Active Transport and Biogenesis. The special features of informality and spontaneity of Gordon Conferences allow the possibility of in-depth discussions of fundamental questions. To further stimulate such discussions, to the extent that it is feasible, this Conference is being organized around conceptual themes rather than focused on individual proteins or experimental systems. This is a bit of an experiment, but I believe it will be interesting. The major use of the funds requested in this application is to support the attendance at this conference of "young" people, graduate students and postdoctorals. Forty-six students and postdocs, out of a total of 145 in attendance, came to the last Conference. The research discoveries, relevance of spectoscopic methods, and quantitative analysis of integral membrane proteins make it essential to educate, and inform the young researchers interested in this field, who will form its next generation. The Bioenergetics GRC is a wonderfully inspiring venue for these purposes. Of course, the ideas and studies contributed by the younger folks are also inspirational to the rest of us.