INTERNATIONAL BARI WORKSHOP ON MITOCHONDRIA

国际 BARI 线粒体研讨会

• 批准号: 6352237
• 负责人: RONALD A BUTOW
• 金额: $ 1万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352237
• 关键词: aging; apoptosis; international health /scientific organization; mitochondria; neuromuscular disorder; oxidative stress; travel; workshop

DESCRIPTION (provided by applicant) This application is to request funds to support the travel expenses of 14 US and 3 Canadian scientist as invited speakers to an international workshop on Mitochondria: Evolution, Genomics, Homeostasis and Pathology, to be held from May 9, 2001 to May 12, 2001, in Martina Franca, Italy. The meeting is one of a long-standing series of Bari conferences, which have traditionally dealt with various aspects of mitochondrial biology. The meeting is being organized jointly by the Principal investigator and by Dr. Cecilia Saccone, from the University of Bari. The objective of the meeting is to bring together internationally recognized experts and interested investigators from North America and Europe, whose primary research interests are not only in the basic principles of mitochondrial physiology and molecular biology, but in areas such as aging, oxidative stress, apoptosis and neuromuscular diseases-problems which have fundamental links to perturbations in mitochondrial function. The meeting will have three major themes: 1) genomics and the evolution of mitochondria and mitochondrial DNA. Included will be discussions of the development and use of data bases representing compendia of genes encoding mitochondrial proteins and the cis and trans acting elements controlling mitochondrial biogenesis and inheritance in organisms from yeast to man; 2) mitochondrial homeostasis, which includes nuclear-mitochondrial interactions, the control of mitochondrial biogenesis, expression of mitochondrial genomes, and the inheritance of mitochondria and mitochondrial DNA; 3) mitochondrial pathologies-how oxidative stress, alterations in mitochondrial function and attendant alterations in metabolism may be related to the process of aging, apoptosis and the manifestation of neuromuscular disorders due to mitochondrial DNA mutations, rearrangements and segregational defects.

描述（由申请人提供） 这份申请是为了申请资金来支持14名美国人的旅行费用。 和3名加拿大科学家作为特邀演讲人参加了一个关于 线粒体：进化，基因组学，稳态和病理学， 2001年5月9日至2001年5月12日，在意大利马蒂纳弗兰卡。 这次会议是 一系列长期存在的巴里会议，传统上处理 线粒体生物学的各个方面。 会议正在组织中 由主要研究者和来自 巴里大学。 会议的目的是汇集 国际公认的专家和感兴趣的调查人员， 美国和欧洲，他们的主要研究兴趣不仅是在基础 线粒体生理学和分子生物学原理，但在 如衰老、氧化应激、细胞凋亡和神经肌肉疾病等问题 这与线粒体功能的紊乱有着根本的联系。 的 会议将有三大主题：1）基因组学和进化 线粒体和线粒体DNA。 其中将讨论 代表基因编码概要的数据库的开发和使用 线粒体蛋白质和顺式和反式作用元件控制 从酵母到人的生物体中的线粒体生物发生和遗传; 2） 线粒体稳态，包括核-线粒体相互作用， 线粒体生物发生的控制，线粒体基因组的表达， 线粒体和线粒体DNA的遗传; 病理学-如何氧化应激，线粒体功能的改变， 伴随的代谢改变可能与衰老过程有关， 细胞凋亡和神经肌肉疾病的表现，由于 线粒体DNA突变、重排和分离缺陷。