THREE-DIMENSIONAL ELECTRON MICROSCOPY OF MACROMOLECULES

大分子三维电子显微镜

• 批准号: 6359894
• 负责人: ROBERT M GLAESER
• 金额: $ 0.7万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359894
• 关键词: bioimaging /biomedical imaging; biomedical automation; electron microscopy; high throughput technology; meeting /conference /symposium; structural biology; tomography; travel

DESCRIPTION (provided by applicant): This proposal requests support for the ninth Gordon Research Conference on Three-Dimensional Electron Microscopy of Macromolecules. Electron microscopy occupies a unique position in the biological armamentarium in that it can address questions at the molecular and cellular level that cannot be approached using other structural methods. In recent years, important technical breakthroughs have been made which enable three-dimensional structures to be determined with ever increasing accuracy, and which have opened the way to the study of macromolecular systems under defined physiological conditions. As a result, there are exciting new opportunities for understanding biological mechanisms, interactions between macromolecules and the principles of bio-molecular design. This series of conferences fosters an integrated view of biological complexity by bringing together scientists working at different levels of the structural hierarchy. These meetings serve to define the challenges of the future and to focus a concerted approach to problems in the preparation, imaging and interpretation of biological specimens that range in size from the molecular to the subcellular. The impact of the preceding eight conferences has been such that the 3D EM community has come to regard this Gordon Conference as an event of pivotal importance. The theme of the conference in 2001 is "High Throughput At High Resolution." In organizing this conference, our goal has been to create a dynamic forum for (i) the dissemination of the major progress in the field over the past two years and (ii) identification of the new technical and biological challenges which the field must address in order for 3D EM to become an essential and ubiquitous tool for the solution of cell biological problems. In the spirit of the Gordon Conference, we have chosen a program that represents the frontier of our field. Speakers have been chosen on the basis of the importance of their recent contributions and the potential impact of their particular research approach. Based on past experience, we confidently expect that the 3D EM Gordon Conference will continue to play a central role in defining new technical challenges, and in focusing a concerted approach to the understanding of fundamental biological questions.

描述（由申请人提供）：本提案要求支持 第九届戈登三维电子显微镜研究会议 大分子。电子显微镜在生物医学中占有独特的地位。 生物医疗设备，因为它可以解决问题，在分子和 细胞水平，不能接近使用其他结构的方法。在 近年来，已经取得了重要的技术突破， 三维结构将以不断增加的精度被确定， 并开辟了研究大分子系统的道路， 定义的生理条件。因此，有令人兴奋的新 了解生物机制的机会， 大分子和生物分子设计的原则。 这一系列的会议促进了生物复杂性的综合观点 通过将科学家聚集在一起， 等级制度。这些会议有助于确定未来的挑战， 集中协调一致的方法来解决准备、成像和 生物样本的大小范围从分子到 亚细胞前八次会议的影响是这样的， 3D EM社区已经开始将这次戈登会议视为一个事件， 至关重要 2001年会议的主题是"高分辨率的高分辨率"。"在 组织这次会议，我们的目标是创造一个充满活力的论坛， 宣传过去两年在该领域取得的重大进展 和（ii）确定新的技术和生物挑战， 该领域必须解决，以便使三维EM成为一个必不可少的和普遍存在的 解决细胞生物学问题的工具。本着戈登的精神 会议上，我们选择了一个代表我们领域前沿的项目。 发言人是根据他们最近的重要性选择的。 他们的贡献和他们特定研究方法的潜在影响。 根据以往的经验，我们确信3D EM Gordon 会议将继续发挥核心作用，确定新的技术 挑战，并集中采取协调一致的办法， 基本的生物学问题。