CONFERENCE ON CONTROL OF VIRAL LATENCY AND PERSISTENCE

描述：几个病毒家族的成员(例如，腺病毒， 细小病毒、乳头瘤病毒、乳头状病毒、疱疹病毒、逆转录病毒、 等)在人类细胞中主要但不完全是通过建立 持续性或潜伏性感染。在潜伏感染的过程中，病毒 基因组保留在上体状态或整合到细胞中 染色体但保留复制能力并导致显著的 发病率。近年来，新工具的应用基于 蛋白质-蛋白质相互作用、基因组学、DNA阵列等显著 加深了我们对病毒致病机制多样性的理解 建立延迟。在许多关键发现中，包括对病毒和 与建立潜伏期和重新激活有关的细胞功能 从潜伏状态。同样重要的是，目前对抑制心理障碍的研究 重新激活以及在存在的情况下故意重新激活潜伏病毒 抗病毒药物。延迟是国际上常见但很小的组成部分 以及病毒学方面的全国性会议。病毒学会议的分裂 以病毒家族为基础的众多研讨会，有时只有基本的 科学或临床组件，同时出现巨大的 发表病毒学通讯的期刊排除了有意义的 更年轻和更成熟的科学家在不同领域的互动 潜伏期或不同病毒家族的工作人员之间的潜伏期。在最近 多年来，还没有完全致力于病毒潜伏期的科学会议， 持久性和延迟控制。这个新的基石的意图是 会议的目的是将当前的科学新手(研究生)聚集在一起 和博士后实习生)、关键研究人员和从事 病毒持久性的基本方面以及努力控制和 最终根除潜伏的病毒。我们希望这次会议能有一个 对未来研究的开创性影响以及吸引新一代 科学家们来到这一领域。

DESCRIPTION: Members of several families of viruses (e.g. adenovirus, parvoviruses, papillomaviruses, papovaviruses, herpesviruses, retroviruses, etc.) persist in human cells principally but not exclusively by establishing persistent or latent infections. In the course of latent infections, viral genomes are retained in an episomal state or become integrated into cellular chromosomes but retain the capacity to replicate and to cause significant morbidity. In recent years the application of novel tools based on protein-protein interactions, genomics, DNA arrays, etc. have significantly advanced our understanding of the diversity of mechanisms by which viruses establish latency. Among many key findings are identification of viral and cellular functions involved in the establishment of latency and reactivation from latent state. Equally important is the current research on suppression of reactivation and on deliberate reactivation of latent viruses in the presence of antiviral drugs. Latency is a frequent but small component of international and national meetings in virology. The splintering of meetings in virology into numerous workshops based on virus families, sometimes with only basic science or clinical components, concurrent with a huge proliferation of journals publishing virological communications has precluded meaningful interaction among younger and more established scientists in the various aspects of latency or between workers in diverse virus families. In recent years there has been no scientific meeting totally dedicated to viral latency, persistence, and control of latency. The intent of this new Keystone conference is to bring together current entrants to science (graduate students and postdoctoral trainees), key investigators, and newcomers working on fundamental aspects of viral persistence and on the efforts to control and ultimately eradicate latent viruses. We hope that the meeting will have a seminal impact on future research as well as attract a new generation of scientists to this field.